The biochemical mode of inhibition of DNA polymerase β by α-rubromycin

Y Mizushina, T Ueno, M Oda, T Yamaguchi… - … et Biophysica Acta (BBA …, 2000 - Elsevier
… that the antibiotics were animal DNA polymerase inhibitors; α-rubromycin is a rare inhibitor
that can potently inhibit the pol. β activity, and β-rubromycin is a telomerase inhibitor [10]. We …

Rubromycins: A Class of Telomerase Inhibitor Antibiotics Produced by Streptomyces spp.

AZ Boumehira, H Hacène, HA El-Enshasy - New and Future Developments …, 2019 - Elsevier
… This makes telomerase a very attractive biological marker … The inhibitory molecules can act
directly on the subanalytical … inhibit several enzymes such as the DNA polymerases, retroviral …

Anti-cancer targeting telomerase inhibitors: β-rubromycin and oleic acid

Y Mizushina, T Takeuchi, F Sugawara… - Mini reviews in …, 2012 - ingentaconnect.com
… scientists in the molecular biological process of reverse-transcription polymerase chain
reaction (… transcriptases, viral RNA polymerases and bacteriophage B-family DNA polymerases. …

Telomere maintenance as a target for drug discovery

V Sekaran, J Soares, MB Jarstfer - Journal of medicinal chemistry, 2014 - ACS Publications
… is inhibited, DNA replication attending cellular proliferation results in telomeric DNA erosion.
… , and our increased understanding of telomere biochemistry and biology is sure to inform …

Telomeres and telomerase as targets for cancer therapy

S Zimmermann, UM Martens - Cellular and molecular life sciences, 2007 - Springer
… transferase, classifying it as a more diversified DNA polymerase inhibitor [19, 20]. … (2000)
The biochemical mode of inhibition of DNA polymerase beta by alpha-rubromycin. …

The inhibitory effect of Curcuma longa extract on telomerase activity in A549 lung cancer cell line

P Mohammad, Z Nosratollah, R Mohammad… - African Journal of …, 2010 - ajol.info
… telomeric ends of eukaryotic chromosomes during DNA replication. It has been shown that
… the biochemical mode of inhibition of DNA polymerase beta by alpha-rubromycin. Biochim. …

Vliv polyketidových antibiotik na signalizaci a funkční aktivitu lidské monocytární linie

K Kopecká - 2015 - dspace.cuni.cz
… For this purpose we use various immunosuppressant drugs, and biological treatment is
used, too. Another possibility is to use bioactive secondary metabolites produced by various …