… sheep in the current study during the first few minutes after administration of meperidine or
alfentanil… with stimulation was previously recorded in awake sheep, [13] and the time course …

… In conclusion, pharmacokinetic modelling of oxycodone … In contrast, morphine has a small
cerebral distribution volume … to determine the cerebral kinetics of other opioids (eg alfentanil, …

… We compared the pharmacokinetic/pharmacodynamic and mass-balance methods for propofol,
methohexital, and ketamine in a sheep model. Both methods give similar values for t ½ K …

… Cerebral pharmacokinetics were determined from simultaneous measurements of arterial
… experimental conditions in conscious instrumented sheep. Data for alfentanil and pethidine …

… In conscious sheep, the half-lives of equilibrium between blood and brain were 0.8 and 6.3
min for alfentanil and meperidine, … Upton et al. 10found that large differences in the cerebral …

… sheep preparation enables uptake and elution of drug in the brain to be determined in
conscious … Citation2003), indicating that norBUP has a higher brain tissue affinity than morphine …

… cerebral kinetics of alfentanil, pethidine 7 and morphine 8 using a chronically instrumented
sheep … The cerebral pharmacokinetics was determined from simultaneous measurements of …

… , pharmacokinetic–pharmacodynamic modelling of LAAM should account for the large
equilibration delay between brain … (iv) infusion in conscious chronically instrumented sheep. Such …

… In conclusion, pharmacokinetic modelling of methadone confirmed a large equilibration …
The cerebral pharmacokinetics of meperidine and alfentanil in conscious sheep. Anesthesiology …

… pharmacokinetic data regarding intravenous butorphanol, fentanyl, and morphine … ,59
potent opioids such as fentanyl, sufentanil, and alfentanil, have been used to produce "balanced …