The phosphodiesterase 3 inhibitor cilostazol does not stimulate growth of colorectal liver metastases after major hepatectomy

MJ Strowitzki, S Dold, M von Heesen, C Körbel… - … experimental metastasis, 2014 - Springer
… regeneration also stimulate intrahepatic metastatic growth. Therefore, this … of cilostazol on
engraftment, vascularization and growth of colorectal liver metastasis after major hepatectomy. …

[PDF][PDF] Cilostazol improves hepatic blood perfusion, microcirculation, and liver regeneration after major hepatectomy in rats

M von Heesen, S Dold, S Müller, C Scheuer… - Liver …, 2015 - Wiley Online Library
… far, no treatment is available to improve liver regeneration. Herein, we studied whether
cilostazol, a selective phosphodiesterase III inhibitor, isgrowth factor expression, an increase of …

Cilostazol improves the prognosis after hepatectomy in rats with sinusoidal obstruction syndrome

H Sugita, S Nakanuma, S Munesue… - Journal of …, 2024 - Wiley Online Library
hepatectomy is important for patients with colorectal liver … of cilostazol (CZ), an oral selective
phosphodiesterase III … VWF in zone 3 and the increase in blood HA levels after hepatectomy …

Phosphodiesterase type III inhibitor, cilostazol, inhibits colon cancer cell motility

K Murata, M Kameyama, F Fukui, H Ohigashi… - … experimental metastasis, 1999 - Springer
… did not induce cell invasion in this assay system (not shown). … with liver metastatic tumor
were significantly increased by … two-thirds hepatectomy in rats. Oncology 1998; 55: 354–6. 12…

Cilostazol induces apoptosis and inhibits proliferation of hepatocellular carcinoma cells by activating AMPK

KH Sim, MS Shu, S Kim, JY Kim, BH Choi… - Biotechnology and …, 2021 - Springer
… Kollmar, and MD Menger (2014) The phosphodiesterase 3 inhibitor cilostazol does not
stimulate growth of colorectal liver metastases after major hepatectomy. Clin. Exp…

Cilostazol attenuates cholestatic liver injury and its complications in common bile duct ligated rats

HSA Kawy - European journal of pharmacology, 2015 - Elsevier
Cilostazol is a phosphodiesterase III inhibitor increases adenosine … of cilostazol on engraftment,
vascularization and growth of colorectal liver metastasis after major hepatectomy in WAG…

Platelet-targeted pharmacologic treatments as anti-cancer therapy

P Gresele, S Momi, M Malvestiti… - Cancer and Metastasis …, 2017 - Springer
… Different isoforms of phosphodiesterases are present in … Combination therapy with cisplatin
and cilostazol may increase the … lobe in non-hepactomized rats and in 2/3 hepatectomized

Rapamycin inhibits hepatectomy-induced stimulation of metastatic tumor growth by reduction of angiogenesis, microvascular blood perfusion, and tumor cell …

K Rupertus, C Dahlem, MD Menger… - Annals of surgical …, 2009 - Springer
… survival after surgical resection of colorectal liver metastasis isgrowth of colorectal metastases
stimulated by hepatectomy-… of inhibiting the growth of extrahepatic colorectal metastases

Phosphodiesterase 3A represents a therapeutic target that drives stem cell–like property and metastasis in breast cancer

N Hao, W Shen, R Du, S Jiang, J Zhu, Y Chen… - Molecular Cancer …, 2020 - AACR
… the stemness of colorectal cancer. More interestingly, it … -selective inhibitor cilostazol
reduces breast cancer cell stem cell… –metastasis environment are thought to promote breast …

Cilostazol has beneficial effects in treatment of intermittent claudication: results from a multicenter, randomized, prospective, double-blind trial

DL Dawson, BS Cutler, MH Meissner… - Circulation, 1998 - Am Heart Assoc
… Background—Cilostazol is a new phosphodiesterase inhibitor … suggested that cilostazol
increases dermal blood flow, 3 augments … The drug inhibits replication and growth of rat vascular …