… of models is most predictive of clinical treatment efficacy. … role of our in vitro time kill-kinetics
assay as an asset to a predictive preclinical modeling framework assessing anti-tuberculosis …

… of assessing and reporting PKPD of anti-tuberculosis drugs when … the extent of the drug
by performing time-kill kinetic studies, … pre-clinical models are useful in the tuberculosis drug …

… , several pre-clinical animal and in vitro efficacy models are … Our imaging data, measuring
the intracellular Mtb response … Time-kill kinetics of anti-tuberculosis drugs, and emergence …

… For rapid anti-tuberculosis (TB) drug development in vitro … the related mathematical modeling
approaches of time–kill data. … to quantify in humans, preclinical models in animals and in …

… The stability of the drugs allowed assessment of activity during the 6 … to evaluate and
describe PD interaction of the three drugs in duo and triple combinations as studied in the time–kill …

… In vitro time kill-kinetics assays can be adopted in a predictive preclinical modelling
framework to assess anti-tuberculosis drug activity. This provides important information on the …

… were studied in static time-kill experiments. A sigmoidal … modeling framework to assess
the combined action of anti-TB … We believe that preclinical response-surface modeling of …

… Therefore, as described in this paper, time-kill kinetics assays … The role of the time-kill
kinetics assay as part of a preclinical … of anti-tuberculosis drugs. Tuberculosis (Edinb) 105:80–85. …

… trials that assess the safety, tolerability, drug exposure, and … on preclinical mouse studies
that included pretomanid time-kill and … cell division and mass action kinetics for drug-receptor …

… on in vitro experiments or even pre-clinical efficacy data as … of antibiotic penetration and
activity that lead granulomas to … We evaluate TB treatment using our computational model …