… the MIC for most of the time the patient is taking the drug. This review will evaluate how well
this paradigm predicts the effectiveness of treatment with antimycobacterial agents. Common …

… suitable animal models to predict efficacy, a poor understanding of … Since antimicrobial
efficacy in an in vitro model relates to the rate … A critical review of PK/PD in in vitro models. Int. J. …

… valuable for early predictions of a drug effect, where … review provides an overview of available
pharmacokinetic-pharmacodynamic models of antibacterial drugs that are based on in vitro…

… In vitro pharmacokinetic models are excellent tools with which to study an antibacterial's …
parameters which predict fluoroquinolone antibacterial effect and emergence of resistance …

… of antibacterial agents, treatment typically requires the use of … convincing in vitro models to
predict the sterilizing activity of … to ascertain the predictive value of these pharmacokinetic and …

Frontiers | The importance of pharmacokinetics and pharmacodynamics in antimicrobial drug
development and their influence on the success of agents developed to combat resistant …

… , in vitro and in vivo pharmacokinetic and pharmacodynamic … is not a predictor of activity
inside the mycobacterium, at least … compounds, mouse in vivo PK and efficacy data were either …

… of antimicrobial effect include microbial kill, acquired drug … can be calculated ex vivo and then
translated to the clinic. … C max /MIC as most predictive of speed of sterilizing effect, whereas …

… pharmacokinetic data or had a dose-scheduling design. Without exception, the antimicrobial
PK/PD parameters linked to optimal effect … Thus, exposure-effect relationships derived in the …

… review provides a critical analysis of the pharmacokinetics of … is the predictive PD parameter
related to maximum efficacy. … In vitro and in vivo PD studies have demonstrated that C max …