Thermally-prepared polymorphic forms of cilostazol

GW Stowell, RJ Behme, SM Denton, I Pfeiffer… - Journal of …, 2002 - Elsevier
… In the case of cilostazol, an antithrombotic agent, the only crystalline form reported … cilostazol
and potentially improve its bioavailability, an investigation into potential polymorphic forms

[HTML][HTML] Comparative study of different crystallization methods in the case of cilostazol crystal habit optimization

T Tari, P Szabó-Révész, Z Aigner - Crystals, 2019 - mdpi.com
cilostazol is limited owing to its poor aqueous solubility and oral bioavailability. Our aim was
to produce cilostazol … size distribution and stable polymorphic form to increase its dissolution …

Physical and dissolution characterization of cilostazol solid dispersions prepared by hot melt granulation (HMG) and thermal adhesion granulation (TAG) methods

YC Chen, HO Ho, JD Chiou, MT Sheu - International journal of …, 2014 - Elsevier
… powder, thus the crystalline form of a compound is always less soluble than the corresponding
amorphous form (Ansel et al., 1999). Furthermore, when the ratio of cilostazol:TPGS was …

[PDF][PDF] Hydrophilic sugars for enhancing dissolution rate of cilostazol: effect of wet co-processing

AY Bazeed, A Nouh, EA Essa… - Pharmaceutical …, 2020 - ps.tbzmed.ac.ir
… cooling of cilostazol is believed to result in polymorphic transition… It may possibly reflect
polymorphic transition of the drug in … Polymorphism has been reported for cilostazol upon thermal …

The investigation of MCM-48-type and MCM-41-type mesoporous silica as oral solid dispersion carriers for water insoluble cilostazol

Y Wang, L Sun, T Jiang, J Zhang, C Zhang… - Drug development …, 2014 - Taylor & Francis
… for the stable crystalline form of CLT is 159 CCitation40, while the amorphous form had no
… was evidence that there might be a crystalline transition during the drug loading procedure. …

Can crystal engineering be as beneficial as micronisation and overcome its pitfalls?: A case study with cilostazol

KS Gouthami, D Kumar, R Thipparaboina… - International journal of …, 2015 - Elsevier
… of cilostazol by crystal engineering, using habit modification method and compare with
micronized cilostazolpolymorphic forms, of which form A is the most stable form. The other two …

Preparation and optimization of glyceryl behenate-based highly porous pellets containing cilostazol

KM Hwang, W Byun, CH Cho… - Pharmaceutical …, 2018 - Taylor & Francis
… reported cases of cilostazol polymorphism after melting and coolingCitation 40 , the sintering
temperature used in this study was not high enough to alter its crystalline form. The FTIR …

[HTML][HTML] An oral formulation of cilostazol nanoparticles enhances intestinal drug absorption in rats

C Yoshioka, Y Ito, N Nagai - Experimental and …, 2018 - spandidos-publications.com
… Therefore, we are now investigating the effect of each of the CLZ polymorphic forms (Form
AC) in the CLZ/Rnano tablet on stability in re-dispersion, drug absorption, and treatment of …

[HTML][HTML] Cilostazol-loaded poly (ε-Caprolactone) electrospun drug delivery system for cardiovascular applications

M Rychter, A Baranowska-Korczyc, B Milanowski… - Pharmaceutical …, 2018 - Springer
… B, which may spontaneously convert overtime back to form A … incorporation of the hydrophobic
drug - cilostazol (CIL) into the … Our study demonstrates no change in CIL polymorphic form

A systematic approach to design and prepare solid dispersions of poorly water-soluble drug

S Verma, VS Rudraraju - AAPS PharmSciTech, 2014 - Springer
… For this investigation, cilostazol (CIL) was selected as model drug, which was classified as a
… 6 and 7) all proved that the sample of CIL received was crystalline and polymorphic form A (…