… deficiency impaired neutrophil apoptosis via pulmonary up-regulation of Bcl-2, thereby resulting
in deteriorated AHR and airway inflammation, … the development of TDI-induced asthma. …

… and correlated to impaired lung function and asthma severity.Initial … attenuated airway
hyperresponsiveness (AHR) and inflammation in … Toll-like receptor 4 deficiency aggravates airway …

… airway hyper-responsiveness and airway inflammation, … via pattern recognition receptors
that recruit apoptosis-associated … was also related to neutrophilic airway inflammation. NLRP3 …

… toll-like receptor 4 … C) Measurement of airway hyper-responsiveness by lung resistance (n
= 6). D) Numbers of … Neutrophil apoptosis has been reported to prevent TDI-induced AHR and …

… , TDI-induced airway hyperresponsiveness (AHR) and … (Pred) treatment in the murine model
[4]. Thus, understanding the … Low frequency or impaired function of Treg cells is observed …

… immune responses mainly via Toll-like receptor 4 (TLR4) that … significantly enhanced
airway hyperresponsiveness and … deficiency may possibly contribute to impaired neutrophil …

… , Toll-like receptor 4 expression, airway inflammation, and bronchial hyperresponsiveness,
… this study we used 2 types of murine models for bronchial asthma: OVA LPS -OVA mice and …

… , airway hyperresponsiveness (AHR), and inflammatory … with other PRR such as the Toll-like
receptors (TLR) (38). … MCC950 to a toluene diisocyanate-induced asthma model blocked the …

… (TRIF), an adapter protein of Toll-like receptors (TLRs). Eventually, … defect of TLR4 causes
impaired neutrophil apoptosis by up-… airway inflammation and airway hyperresponsiveness in …

… .5-induced AHR in mice with asthma was due to exacerbated M2 … impairing the differentiation
of Treg cells, thereby exacerbating … AHR by inducing cell apoptosis and necroptosis. Both …