[HTML][HTML] Transcription Factor OpWRKY3 Is Involved in the Development and Biosynthesis of Camptothecin and Its Precursors in Ophiorrhiza pumila Hairy Roots

C Wang, C Wu, Y Wang, C Xie, M Shi, S Nile… - International journal of …, 2019 - mdpi.com
… have been reported to play important roles in plant metabolism and development. In this
study, a novel WRKY transcription factor named OpWRKY3 was isolated from O. pumila, with full…

WRKY transcription factor OpWRKY1 acts as a negative regulator of camptothecin biosynthesis in Ophiorrhiza pumila hairy roots

M Xu, C Wu, L Zhao, Y Wang, C Wang, W Zhou… - Plant Cell, Tissue and …, 2020 - Springer
… Meanwhile, OpWRKY3 may be a positive regulator of hairy root growthOpWRKY3 not only
affected growth and development but also promoted the production of CPT and its precursors

Identification of WRKY transcription factors involved in regulating the biosynthesis of the anti-cancer drug camptothecin in Ophiorrhiza pumila

C Wang, X Hao, Y Wang, I Maoz, W Zhou… - Horticulture …, 2022 - academic.oup.com
pumila hairy roots caused by overexpression of OpWRKY3 … of camptothecin, also promoting
the transcription of OpCPR [28… may be involved in regulating camptothecin and its precursor

The transcription factor OpWRKY2 positively regulates the biosynthesis of the anticancer drug camptothecin in Ophiorrhiza pumila

X Hao, C Xie, Q Ruan, X Zhang, C Wu… - Horticulture …, 2021 - academic.oup.com
… regulates camptothecin biosynthesis, and OpWRKY3 plays a … pumila hairy roots at
different growth stages was … pumila at different growth stages, a single transcription factor

[HTML][HTML] Genome-wide survey of the GATA gene family in camptothecin-producing plant Ophiorrhiza pumila

M Shi, Q Huang, Y Wang, C Wang, R Zhu, S Zhang… - BMC genomics, 2022 - Springer
Transcription factors (TFs) GATA are a group of transcription … stem, roots, leaves, cell
suspension cultures and hairy roots, … novel OpGATA TFs involved in regulating CPT biosynthesis. …

OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O‐methyltransferase in Ophiorrhiza pumila

X Hao, C Wang, W Zhou, Q Ruan, C Xie… - Journal of Integrative …, 2023 - Wiley Online Library
… In general, strictosidine is the precursor for camptothecin biosynthesis in O. … In our study,
loganin and camptothecin were not detected in OpLAMT1-KO hairy root lines. Furthermore, we …

Genome-wide Survey of the GATA Gene Family in Camptothecin-producing Plant Ophiorrhiza Pumila

Q Huang, M Shi, C Wang, J Hu, G Kai - 2021 - researchsquare.com
Transcription Factor OpWRKY3 Is Involved in the … Precursors in Ophiorrhiza pumila Hairy
Roots. Int J Mol Sci. 2019;… of camptothecin biosynthesis in Ophiorrhiza pumila hairy roots. Plant …

The regulatory aspects of plant transcription factors in alkaloids biosynthesis and pathway modulation

P Prakash, R Kumar, V Gupta - Plant Transcription Factors, 2023 - Elsevier
… OpMYB1 TF regulates camptothecin biosynthesis in Ophiorrhiza pumila. OpMYB1 … pumila
hairy roots. The study suggests that OpWRKY3 acts as a potential regulator of camptothecin

[HTML][HTML] Chromosome-level genome assembly of Ophiorrhiza pumila reveals the evolution of camptothecin biosynthesis

A Rai, H Hirakawa, R Nakabayashi, S Kikuchi… - Nature …, 2021 - nature.com
… , is the precursor for the commercial synthesis of topotecan … gene models, including 778
transcription factors (TFs), 2827 … the Ophiorrhiza root and hairy roots are the sites of active …

Research progress on the biosynthesis and metabolic engineering of the anti-cancer drug camptothecin in Camptotheca acuminate

X Fan, X Lin, Q Ruan, J Wang, Y Yang, M Sheng… - Industrial Crops and …, 2022 - Elsevier
transcription factors, such as the bZIP transcription factorpumila hairy roots, the accumulation
of camptothecin was … , and OpWRKY3 enhanced camptothecin production mainly by …