Tumor–stromal cell interaction under hypoxia increases the invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c‐Met pathway
T Ide, Y Kitajima, A Miyoshi, T Ohtsuka… - … journal of cancer, 2006 - Wiley Online Library
… system to evaluate tumor–stromal cell interaction under hypoxia. Using this system, we
analyzed whether hypoxia enhances the invasive activity of pancreatic cancer cells, while also …
analyzed whether hypoxia enhances the invasive activity of pancreatic cancer cells, while also …
The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling
T Ide, Y Kitajima, A Miyoshi, T Ohtsuka… - Annals of surgical …, 2007 - Springer
… tumor-stromal interaction under hypoxia enhances the invasiveness of pancreatic cancer
cells through hepatocyte … the activation of the HGF/c-Met pathway.18 To date, no studies have …
cells through hepatocyte … the activation of the HGF/c-Met pathway.18 To date, no studies have …
… of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c‐Met system via hypoxia inducible factor‐1 in pancreatic …
Y Kitajima, T Ide, T Ohtsuka, K Miyazaki - Cancer science, 2008 - Wiley Online Library
… We have revealed that tumor–stromal cell interaction under hypoxia increases the
invasiveness of pancreatic cancer cells through the HGF/c-Met pathway ( 21 ) and therefore …
invasiveness of pancreatic cancer cells through the HGF/c-Met pathway ( 21 ) and therefore …
MET/HGF co-targeting in pancreatic cancer: a tool to provide insight into the tumor/stroma crosstalk
C Modica, D Tortarolo, PM Comoglio… - International journal of …, 2018 - mdpi.com
… binding sites for transcription factors, including hypoxia-inducible … the invasive growth
program, in which cancer cells acquire the ability to disrupt cell-to-cell interactions, migrate through …
program, in which cancer cells acquire the ability to disrupt cell-to-cell interactions, migrate through …
Hepatocyte growth factor from a clinical perspective: A pancreatic cancer challenge
W Rizwani, AE Allen, JG Trevino - Cancers, 2015 - mdpi.com
… with enhanced invasion of pancreatic cancer cells with only high … hypoxic environment in
pancreatic cancers and limits cancer … -stroma interactive loop exists and facilitates tumor growth …
pancreatic cancers and limits cancer … -stroma interactive loop exists and facilitates tumor growth …
Hypoxia activated HGF expression in pancreatic stellate cells confers resistance of pancreatic cancer cells to EGFR inhibition
… induced the expression and secretion of HGF in PSC via transcription … of pancreatic cancer
cells to EGFR inhibitor in a KRAS-independent manner by activating the PI3K-AKT pathway. …
cells to EGFR inhibitor in a KRAS-independent manner by activating the PI3K-AKT pathway. …
The impact of hypoxia in pancreatic cancer invasion and metastasis
A Yuen, B Díaz - Hypoxia, 2014 - Taylor & Francis
… hypoxia has on the ability of pancreatic cancer cells to invade and metastasize. Hypoxia
activates signaling pathways in both cell-… -invasive interactions between cancer and stromal cells…
activates signaling pathways in both cell-… -invasive interactions between cancer and stromal cells…
Targeting HGF/c-MET axis in pancreatic cancer
… is the hepatocyte growth factor (HGF)/c-MET pathway. HGF … the invasiveness of a pancreatic
cancer cell line (PK8) that … from fibroblast cell line (MRC5) under hypoxic conditions; …
cancer cell line (PK8) that … from fibroblast cell line (MRC5) under hypoxic conditions; …
Hepatocyte growth factor in invasive growth of carcinomas
MA Desiderio - Cellular and molecular life sciences, 2007 - Springer
… HGF and tumor stromal cells Solid tumors are not just a mass of neoplastic … the invasiveness
of pancreatic cancer cells through the hepatocyte growth factor/ c-Met pathway. Int. J…
of pancreatic cancer cells through the hepatocyte growth factor/ c-Met pathway. Int. J…