Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans

ALM Bloom, JTG Solomons, VE Havel… - Molecular …, 2013 - Wiley Online Library
… The pathogenic fungus Cryptococcus neoformans must overcome multiple … affects degradation
of RP transcripts during host-temperature adaptation we performed 30C and 37C stability …

mRNA decay: an adaptation tool for the environmental fungal pathogen Cryptococcus neoformans

ALM Bloom, J Leipheimer… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
… specific degradation of subsets of functionally related mRNAs in … major mRNA deadenylase,
CCR4, impairs host temperature … permit mRNA decay to be uncoupled from mRNA synthesis

Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming

ALM Bloom, RM Jin, J Leipheimer, JE Bard… - Nature …, 2019 - nature.com
… , such as Cryptococcus neoformans, is their ability to adapt to … transcript degradation and
mRNA decay in host-temperature … its transcriptome, further impairing its stress responsiveness. …

The ER stress response and host temperature adaptation in the human fungal pathogen Cryptococcus neoformans

VE Glazier, JC Panepinto - Virulence, 2014 - Taylor & Francis
mRNA ligase function to what has been reported in other species (Cryptococcus neoformans
… are tightly regulated, and that mRNA synthesis and degradation are coupled processes in …

Stress Responsive Translation Regulation in the Human Pathogen Cryptococcus neoformans

CM Knowles - 2023 - search.proquest.com
… ) mRNA decay during oxidative stress from H2O2, but is completely dispensable for adaptation
to host temperature stress of 37C… of mRNA synthesis and mRNA decay, known as mRNA

Translational regulation promotes oxidative stress resistance in the human fungal pathogen Cryptococcus neoformans

J Leipheimer, ALM Bloom, CS Campomizzi, Y Salei… - MBio, 2019 - Am Soc Microbiol
… by increased concentrations and incubation temperature. Together, these results indicate …
and mRNA decay that drastically affects the ability of the fungal pathogen to adapt to oxidative …

Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction

CM Knowles, D Goich, ALM Bloom, MC Kalem… - Mbio, 2023 - Am Soc Microbiol
degradation, and mRNA surveillance and decay (26, 32… of Gcn2 to the stress adaptations
we observed in C. … response to temperature is driven mainly by Ccr4-dependent mRNA decay, …

Transcription Factors and Intracellular Proteins Orchestrate Phenotypic Adaptation in Cryptococcus neoformans for Survival and Human Infections

OS Folorunso, OM Sebolai - 2023 - preprints.org
… Furthermore, cytokinesis in these mutants is impaired and … thermal stress temperature induces
a preponderant mRNA … cytokines, GXM also promotes the uncoupling activity of NF-κB to …

Glucan unmasking identifies regulators of temperature-induced translatome reprogramming in C. neoformans

ALM Bloom, D Goich, CM Knowles, JC Panepinto - Msphere, 2021 - Am Soc Microbiol
… and that, while Ccr4-mediated mRNA decay is not a prerequisite for Mpk1 activation, Ccr4
either directly or indirectly modulates Hog1 activation during host temperature adaptation. …

The novel J-domain protein Mrj1 is required for mitochondrial respiration and virulence in Cryptococcus neoformans

LC Horianopoulos, G Hu, M Caza, K Schmitt, P Overby… - MBio, 2020 - Am Soc Microbiol
… normal mammalian body temperature (1). Imperative to this … ] was also used to uncouple
proton motive force from oxygen … The explanation that loss of Mrj1 impairs the ETC at …