Uncoupling of mRNA synthesis and degradation impairs adaptation to host temperature in Cryptococcus neoformans
ALM Bloom, JTG Solomons, VE Havel… - Molecular …, 2013 - Wiley Online Library
… The pathogenic fungus Cryptococcus neoformans must overcome multiple … affects degradation
of RP transcripts during host-temperature adaptation we performed 30C and 37C stability …
of RP transcripts during host-temperature adaptation we performed 30C and 37C stability …
mRNA decay: an adaptation tool for the environmental fungal pathogen Cryptococcus neoformans
ALM Bloom, J Leipheimer… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
… specific degradation of subsets of functionally related mRNAs in … major mRNA deadenylase,
CCR4, impairs host temperature … permit mRNA decay to be uncoupled from mRNA synthesis …
CCR4, impairs host temperature … permit mRNA decay to be uncoupled from mRNA synthesis …
Thermotolerance in the pathogen Cryptococcus neoformans is linked to antigen masking via mRNA decay-dependent reprogramming
ALM Bloom, RM Jin, J Leipheimer, JE Bard… - Nature …, 2019 - nature.com
… , such as Cryptococcus neoformans, is their ability to adapt to … transcript degradation and
mRNA decay in host-temperature … its transcriptome, further impairing its stress responsiveness. …
mRNA decay in host-temperature … its transcriptome, further impairing its stress responsiveness. …
The ER stress response and host temperature adaptation in the human fungal pathogen Cryptococcus neoformans
VE Glazier, JC Panepinto - Virulence, 2014 - Taylor & Francis
… mRNA ligase function to what has been reported in other species (Cryptococcus neoformans
… are tightly regulated, and that mRNA synthesis and degradation are coupled processes in …
… are tightly regulated, and that mRNA synthesis and degradation are coupled processes in …
Stress Responsive Translation Regulation in the Human Pathogen Cryptococcus neoformans
CM Knowles - 2023 - search.proquest.com
… ) mRNA decay during oxidative stress from H2O2, but is completely dispensable for adaptation
to host temperature stress of 37C… of mRNA synthesis and mRNA decay, known as mRNA …
to host temperature stress of 37C… of mRNA synthesis and mRNA decay, known as mRNA …
Translational regulation promotes oxidative stress resistance in the human fungal pathogen Cryptococcus neoformans
J Leipheimer, ALM Bloom, CS Campomizzi, Y Salei… - MBio, 2019 - Am Soc Microbiol
… by increased concentrations and incubation temperature. Together, these results indicate …
and mRNA decay that drastically affects the ability of the fungal pathogen to adapt to oxidative …
and mRNA decay that drastically affects the ability of the fungal pathogen to adapt to oxidative …
Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction
CM Knowles, D Goich, ALM Bloom, MC Kalem… - Mbio, 2023 - Am Soc Microbiol
… degradation, and mRNA surveillance and decay (26, 32… of Gcn2 to the stress adaptations
we observed in C. … response to temperature is driven mainly by Ccr4-dependent mRNA decay, …
we observed in C. … response to temperature is driven mainly by Ccr4-dependent mRNA decay, …
Transcription Factors and Intracellular Proteins Orchestrate Phenotypic Adaptation in Cryptococcus neoformans for Survival and Human Infections
OS Folorunso, OM Sebolai - 2023 - preprints.org
… Furthermore, cytokinesis in these mutants is impaired and … thermal stress temperature induces
a preponderant mRNA … cytokines, GXM also promotes the uncoupling activity of NF-κB to …
a preponderant mRNA … cytokines, GXM also promotes the uncoupling activity of NF-κB to …
Glucan unmasking identifies regulators of temperature-induced translatome reprogramming in C. neoformans
ALM Bloom, D Goich, CM Knowles, JC Panepinto - Msphere, 2021 - Am Soc Microbiol
… and that, while Ccr4-mediated mRNA decay is not a prerequisite for Mpk1 activation, Ccr4
either directly or indirectly modulates Hog1 activation during host temperature adaptation. …
either directly or indirectly modulates Hog1 activation during host temperature adaptation. …
The novel J-domain protein Mrj1 is required for mitochondrial respiration and virulence in Cryptococcus neoformans
… normal mammalian body temperature (1). Imperative to this … ] was also used to uncouple
proton motive force from oxygen … The explanation that loss of Mrj1 impairs the ETC at …
proton motive force from oxygen … The explanation that loss of Mrj1 impairs the ETC at …