Vascular endothelial growth factor-a and islet vascularization are necessary in developing, but not adult, pancreatic islets

RB Reinert, M Brissova, A Shostak, FC Pan… - Diabetes, 2013 - Am Diabetes Assoc
development of islet vascularization. To investigate the role of VEGF-A and endothelial cells
(ECs) in adult islets, … VEGF-A in developing mouse pancreatic and islet progenitor cells or in …

Pancreatic islet production of vascular endothelial growth factor-a is essential for islet vascularization, revascularization, and function

M Brissova, A Shostak, M Shiota, PO Wiebe… - Diabetes, 2006 - Am Diabetes Assoc
… models of how pancreatic islets become so intensely vascularized. In the first model, … of
pancreatic islet vascularization where development of islet vasculature and establishment of islet

Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding

RB Reinert, Q Cai, JY Hong, JL Plank… - …, 2014 - journals.biologists.com
vascularization and innervation of the pancreatic islet. In … neurovascular development within
pancreatic islets, in which … vascular endothelial growth factor A (VEGF), which is crucial for …

Endothelial cells in pancreatic islet development and function

AK Ranjan, MV Joglekar, A Hardikar - Islets, 2009 - Taylor & Francis
… much similar to that of the human pancreatic islets. Both mouse and human islets are well
vascularized and all … factor-A or murine models of type 2 diabetes have different morphology of …

Pancreatic islet hepatocyte growth factor and vascular endothelial growth factor A signaling in growth restricted fetuses

PJ Rozance, WW Hay Jr - Molecular and cellular endocrinology, 2016 - Elsevier
… with mature secretory products, formation of pancreatic islets, … islets, islet vascularity is
decreased in proportion to islet size, … on islet growth, development, and function will be important

[PDF][PDF] Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes β cell regeneration

M Brissova, K Aamodt, P Brahmachary, N Prasad… - Cell metabolism, 2014 - cell.com
… signaling are important for islet differentiation and the formation of highly vascularized islets.
… recruitment to pancreatic islets. Furthermore, understanding signals derived from the intra-…

Vascular instruction of pancreas development

O Cleaver, Y Dor - Development, 2012 - journals.biologists.com
… factors, such as vascular endothelial growth factor A (VEGFA), … islet development or the
potential existence of vascular … One proposal is that enhancement of vascularization might be …

Role of VEGF-A in pancreatic beta cells

H Watada - Endocrine journal, 2010 - jstage.jst.go.jp
… on the increase in beta-cell mass by BMT, we analyzed pancreatic islets of RIP-Cre… Pancreatic
islet production of vascular endothelial growth factor--a is essential for islet vascularization

From endothelial to β cells: insights into pancreatic islet microendothelium

G Camussi, MM Zanone, E Favaro - Current diabetes reviews, 2008 - ingentaconnect.com
… of an endothelialendocrine axis within adult pancreatic islets. … Vascular endothelial growth
factor and its receptors, flt-1 and … factor--a is essential for islet vascularization, revascularization…

Vascular endothelial growth factor–mediated islet hypervascularization and inflammation contribute to progressive reduction of β-cell mass

J Agudo, E Ayuso, V Jimenez, A Casellas, C Mallol… - Diabetes, 2012 - Am Diabetes Assoc
islet vascularization and inflammation was parallel to an increased expression of vascular
endothelial growth factor A (VEGF). … in pancreatic islets from insulin-resistant HFD-fed mice. A: …