The treatment of childhood cancer has been increasingly successful over the past 30 years.
Most paediatric cancers are now curable with multiagent chemotherapy in combination with …

AIMS: The development of sarcomas is a recognized complication of radiation therapy. We
set out to retrospectively review the clinical and therapeutic demographics, as well as the …

PURPOSE: Survivors of childhood and adolescent cancer are at risk for long-term effects of
disease and treatment. The Childhood Cancer Survivor Study assessed overall and cause …

Background: Because survival rates among childhood cancer patients are increasing,
assessing the risk of second and subsequent malignant neoplasms (SMNs) is ever more …

OBJECTIVE: The aim of this study is to evaluate the influence of age at external beam
irradiation (EBRT) on the occurrence of second primary tumors (SPTs) inside and outside …

Short interspersed elements (SINEs), typified by the human Alu repeat, are RNA polymerase
III (pol III)‐transcribed sequences that replicate within the genome through an RNA …

Background Ewing tumor treatment involves high cumulative doses of alkylating agents and
topoisomerase inhibitors, drugs capable of inducing second cancers We analyzed the …

Purposes: To compare the radiation-associated relative risks of cancer incidence and
mortality in groups exposed to ionizing radiation in the course of treatment for a variety of …

Purpose: Extracorporeal irradiation (ECI) has been used selectively in the management of
primary malignant bone tumors since 1996. We report our techniques for ECI and the short …

Recently, several studies have suggested the radiosensitizing effect of taxol, a microtubular
inhibitor. Our overall hypothesis is that a combination of radiation and taxol may …