It has been long known that patients treated with ionizing radiation carry a risk of developing
a second cancer in their lifetimes. Factors contributing to the recently renewed concern …

Osteosarcoma is the most common nonhematologic malignancy of bone in children and
adults. The peak incidence occurs in the second decade of life, with a smaller peak after age …

Background The proportion of pediatric and adolescent cancer patients surviving 5 years
has increased during the past four decades. This growing population of survivors remains at …

Survivors of childhood acute lymphoblastic leukemia (ALL) are at risk for late effects of
cancer therapy. Five-year ALL survivors (< 21 years at diagnosis; n= 5760 eligible, 4151 …

Background Survivors of hereditary retinoblastoma have an elevated risk of developing
second malignancies, but data on the risk in middle-aged retinoblastoma survivors (ie, those …

Sarcomas are a heterogeneous group of tumors that may have many etiologies. The
incidence of histologic subtypes differs significantly between children and adults. The …

Wilms tumour is the most common malignant renal tumour in children. Dramatic
improvements in survival have occurred as the result of advances in anaesthetic and …

PURPOSE: To investigate the cumulative incidence of and the risk factors for developing
second malignant neoplasms (SMN) in children and adolescents following treatment for …

BACKGROUND. The growing number of individuals surviving childhood cancer has
increased the awareness of adverse long‐term sequelae. One of the most worrisome …

BACKGROUND: Patients are at risk of second malignancies (SM) after treatment for Ewing
sarcoma family of tumours (ESFT). METHODS: We performed a retrospective review of 237 …