Despite significant advancements in the diagnosis and treatment of osteosarcoma to date,
overall survival has remained relatively constant for over 2 decades. The challenge in …

Development of a second malignancy is one of the most serious late effects in survivors of
both childhood and adult-onset cancers. Patterns of second malignancy risk across the age …

Background The occurrence of subsequent neoplasms has direct impact on the quantity and
quality of life in cancer survivors. We have expanded our analysis of these events in the …

Previous studies have indicated that thyroid cancer risk after a first childhood malignancy is
curvilinear with radiation dose, increasing at low to moderate doses and decreasing at high …

Abstract Background The survival of Ewing sarcoma (ES) patients has improved since the
1970s but is associated with considerable future health risks. Methods The study population …

The Ewing sarcoma family of tumors (ESFT) consists of a group of tumors characterized by
morphologically similar round-cell neoplasm and by the presence of a common …

A combined cohort of 8,884 North American, 2,893 British and 1,574 Nordic subjects with
Wilms tumor (WT) diagnosed before 15 years of age during 1960–2004 was established to …

Osteosarcoma (OS) is the most common nonhematologic malignancy of bone in children
and adults. Although dysregulation of tumor suppressor genes and oncogenes, such as Rb …

Tumors of the central nervous system, the most common solid tumors of childhood, are a
major source of cancer-related morbidity and mortality in children. Survival rates have …

BACKGROUND: Young adult survivors of childhood cancer have an increased risk for
treatment‐related morbidity and mortality. In this study, the authors assessed how treatment …