Subsequent primary neoplasms: risks, risk factors, surveillance, and future research

M Hawkins, S Bhatia, TO Henderson… - Pediatric …, 2020 - pediatric.theclinics.com
Survivors of childhood cancer experience substantial premature mortality; in the British
Childhood Cancer Survivor Study (BCCSS) cohort, by 50 years from diagnosis 30% of 5 …

Risk of second primary cancer in oral squamous cell carcinoma

R Mroueh, A Nevala, A Haapaniemi, J Pitkäniemi… - Head & …, 2020 - Wiley Online Library
Background The incidence and survival of oral squamous cell carcinoma (OSCC) patients
have increased in recent years. Understanding their long‐term survival aspects is essential …

Impact of different treatment techniques for pediatric Ewing sarcoma of the chest wall: IMRT, 3DCPT, and IMPT with/without beam aperture

Z Su, DJ Indelicato, RB Mailhot… - Journal of Applied …, 2020 - Wiley Online Library
Purpose To evaluate the dosimetric differences between photon intensity‐modulated
radiation therapy (IMRT) plans, 3D conformal proton therapy (3DCPT), and intensity …

Will next-generation immunotherapy overcome the intrinsic diversity and low immunogenicity of sarcomas to improve clinical benefit?

HY Chew, V Chan, F Simpson, R Dolcetti - Cancers, 2020 - mdpi.com
Simple Summary Treatment modalities for sarcoma have not changed significantly for the
past few years despite 25–50% of patients experiencing relapse or progressing to metastatic …

[PDF][PDF] Evaluation of PD1 and PD-L1 expression in high-grade sarcomas of the limbs in the adults: Possible implications of immunotherapy

C Perisano, R Vitiello, A Sgambato… - J. Biol. Regul …, 2020 - researchgate.net
Sarcomas are a heterogeneous group of rare tumours. Improvements in immunotherapy and
the important role of PD1 and PD-L1 expression in advancement and prognosis have …

Craniofacial second primary tumors in patients with germline retinoblastoma previously treated with external beam radiotherapy: A retrospective institutional analysis

I Jiménez, M Laé, ML Tanguy… - Pediatric Blood & …, 2020 - Wiley Online Library
Background The long‐term survival of germline retinoblastoma patients is decreased due to
the risk of second primary tumors (SPTs) that occur years after the diagnosis of …

Soft tissue sarcomas

TF DeLaney, DC Harmon, K Sikora… - Treatment of …, 2020 - taylorfrancis.com
Gastrointestinal stromal tumors (GISTs) recapitulate the interstitial cells of Cajal which have
neural and smooth muscle features, and thus malignant GISTs are also considered a type of …

A case-control study of fluoridation and osteosarcoma

FM Kim, C Hayes, SL Burgard, HD Kim… - Journal of Dental …, 2020 - journals.sagepub.com
Public health policy decisions in the United States have resulted in 62.4% of the population
having access to fluoridated water. The purpose of this study was to examine the association …

Sarcoma as second cancer in a childhood cancer survivor: case report, large population analysis and literature review

TH Nguyen, MR Makena, S Yavvari, M Kaur, T Pham… - Medicina, 2020 - mdpi.com
The majority of pediatric patients are cured of their primary cancer with current advanced
developments in pediatric cancer therapy. However, survivors often experience long-term …

Subsequent primary neoplasms among bone sarcoma survivors; increased risks remain after 30 years of follow-up and in the latest treatment era, a nationwide …

AC Hesla, A Discacciati, P Tsagkozis… - British journal of …, 2020 - nature.com
Background The long-term risks and time trends of subsequent primary neoplasms (SPNs)
among Ewing (ES) and osteosarcoma (OS) survivors are not fully understood. Methods We …