The translation of messenger RNAs (mRNAs) into proteins is a key event in the regulation of
gene expression. This is especially true in the cancer setting, as many oncogenes and …

In addition to the deregulation of gene transcriptions and post-translational protein
modifications, the aberrant translation from mRNAs to proteins plays an important role in the …

Background & Aims Pancreatic ductal adenocarcinoma (PDAC) is characterized by severe
metabolic stress due to fibrosis and poor vascularization. BZW1 is an eIF5-mimic protein …

Dengue virus (DENV) infections cause the most prevalent mosquito-borne viral disease
worldwide, for which no therapies are available. DENV encodes seven non-structural (NS) …

Phosphorylation of the translation initiation factor eIF2 is one of the most widely used and
well‐studied mechanisms cells use to respond to diverse cellular stresses. Known as the …

In eukaryotic translation initiation, AUG recognition of the mRNA requires accommodation of
Met-tRNAi in a 'PIN'state, which is antagonized by the factor eIF1. eIF5 is a GTPase …

Significance: Organisms adapt to changing environments by engaging cellular stress
response pathways that serve to restore proteostasis and enhance survival. A primary …

Salivary gland cancers (SGCs), categorized as head and neck cancers (HNCs), constitute
about 6% of head and neck cancer diagnoses based on estimate by American Head and …

A CGG trinucleotide repeat expansion in the 5′ UTR of FMR 1 causes the
neurodegenerative disorder Fragile X‐associated tremor/ataxia syndrome (FXTAS). This …

Recent technological advancements have shown tremendous mechanistic
accomplishments in our understanding of the mechanism of messenger RNA translation in …