Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

The dorsal horn of the spinal cord is the location of the first synapse in pain pathways, and
as such, offers a very powerful target for regulation of nociceptive transmission by both local …

Chronic pain, whether the result of nerve trauma or persistent inflammation, is a debilitating
condition that exerts a high social cost in terms of productivity, economic impact and quality …

The periaqueductal gray matter (PAG) and the nucleus raphe magnus and adjacent
structures of the rostral ventromedial medulla (RVM), with their projections to the spinal …

Although transcutaneous electrical nerve stimulation (TENS) is used extensively in
inflammatory joint conditions such as arthritis, the underlying mechanisms are unclear. This …

Tissue injury induces enhanced pain sensation to light touch and punctate stimuli in
adjacent, uninjured skin (secondary hyperalgesia). Whereas hyperalgesia to light touch …

Clinically, chronic pain and hyperalgesia induced by muscle injury are disabling and difficult
to treat. Cellular and molecular mechanisms underlying chronic muscle-induced …

Endogenous pain regulatory system dysfunction appears to play a role in the maintenance
of chronic pain. An important component of the pain regulatory process is the functional …

Long-term potentiation (LTP) and long-term depression (LTD) of synaptic strength are
ubiquitous mechanisms of synaptic plasticity, but their functional relevance in humans …

Tissue injury is associated with sensitization of nociceptors and subsequent changes in the
excitability of central (spinal) neurons, termed central sensitization. Nociceptor sensitization …