Eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) are a
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …

The dysfunction of melanocortin signaling has been associated with obesity, given the
important role in the regulation of energy homeostasis, food intake, satiety and body weight …

Calorie-rich diets induce hyperphagia and promote obesity, although the underlying
mechanisms remain poorly defined. We find that short-term high-fat-diet (HFD) feeding of …

Food palatability is one of many factors that drives food consumption, and the hedonic drive
to feed is a key contributor to obesity and binge eating. In this study, we identified a …

The feeding process is required for basic life, influenced by environment cues and tightly
regulated according to demands of the internal milieu by regulatory brain circuits. Although …

Eating disorders are highly sexually differentiated disorders that exhibit a female
predominance in risk. Most theories focus on psychosocial explanations to the exclusion of …

Binge-eating disorder (BED) is the most prevalent eating disorder with estimates of 2–5% of
the general adult population. Nonetheless, its pathophysiology is poorly understood …

Background The prevalence of eating disorders, including binge eating disorder, is
significantly higher in women. These findings are mirrored by preclinical studies, which …

This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …

Nociceptin/orphanin FQ (N/OFQ) is a 17-residue neuropeptide that binds the nociceptin
opioid-like receptor (NOP). N/OFQ exhibits nucleotidic and aminoacidics sequence …