Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design

G Bahr, LJ Gonzalez, AJ Vila - Chemical Reviews, 2021 - ACS Publications
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Acinetobacter baumannii: Emergence of a Successful Pathogen

AY Peleg, H Seifert, DL Paterson - Clinical microbiology reviews, 2008 - Am Soc Microbiol
Acinetobacter baumannii has emerged as a highly troublesome pathogen for many
institutions globally. As a consequence of its immense ability to acquire or upregulate …

Prevalence of VIM- and GIM-producing Acinetobacter baumannii from patients with severe urinary tract infection

SAS Girija, VP Jayaseelan… - Acta microbiologica et …, 2018 - akjournals.com
Carbapenems are administered as the final drug of choice for treating complicated
nosocomial infections caused by multidrug-resistant Acinetobacter baumannii strains. It is …

New β-lactamase inhibitors: a therapeutic renaissance in an MDR world

SM Drawz, KM Papp-Wallace… - Antimicrobial agents and …, 2014 - Am Soc Microbiol
As the incidence of Gram-negative bacterial infections for which few effective treatments
remain increases, so does the contribution of drug-hydrolyzing β-lactamase enzymes to this …

Extended-spectrum-β-lactamase, AmpC, and carbapenemase issues

KS Thomson - Journal of clinical microbiology, 2010 - Am Soc Microbiol
Optimal use of microbiology laboratories is essential to combat the spread of multiply
antibiotic-resistant pathogens. This is vital for patient care, as advocated by Jarvis in …

[HTML][HTML] Acquired carbapenemases in Gram-negative bacterial pathogens: detection and surveillance issues

V Miriagou, G Cornaglia, M Edelstein, I Galani… - Clinical microbiology …, 2010 - Elsevier
Acquired carbapenemases are emerging resistance determinants in Gram-negative
pathogens, including Enterobacteriaceae, Pseudomonas aeruginosa and other Gram …

[HTML][HTML] Detection of carbapenemases in Enterobacteriaceae: a challenge for diagnostic microbiological laboratories

J Hrabák, E Chudáčková, CC Papagiannitsis - Clinical Microbiology and …, 2014 - Elsevier
Carbapenemase-producing bacteria have now spread all over the world. Infections caused
by those bacteria are difficult to treat. Therefore, there is an urgent need for accurate and fast …

Value of the modified Hodge test for detection of emerging carbapenemases in Enterobacteriaceae

D Girlich, L Poirel, P Nordmann - Journal of clinical microbiology, 2012 - Am Soc Microbiol
The modified Hodge test has an excellent sensitivity for detecting enterobacterial isolates
producing Ambler class A (KPC) and class D (OXA-48) carbapenemases. Its sensitivity is …

Outcomes of critically ill intensive care unit patients treated with fosfomycin for infections due to pandrug-resistant and extensively drug-resistant carbapenemase …

K Pontikis, I Karaiskos, S Bastani, G Dimopoulos… - International journal of …, 2014 - Elsevier
Fosfomycin is active in vitro against extensively drug-resistant (XDR) and pandrug-resistant
(PDR) Pseudomonas aeruginosa and Klebsiella pneumoniae carbapenemase-producing …

Detection of Pseudomonas aeruginosa Producing Metallo-β-Lactamases in a Large Centralized Laboratory

JDD Pitout, DB Gregson, L Poirel… - Journal of clinical …, 2005 - Am Soc Microbiol
ABSTRACT Metallo-β-lactamases (MBLs) have been increasingly recognized from clinical
isolates worldwide, but the laboratory detection of these strains is not well defined. We report …