Acute myeloid leukemia (AML) is a heterogeneous disease that is characterized by distinct
cytogenetic or genetic abnormalities. Recent discoveries in cancer epigenetics …

Acute myeloid leukaemia (AML) is a heterogenous disease. Prognosis of AML is influenced
both by patient‐specific as well as disease‐specific factors. Age is the most prominent …

Background Although aberrant DNA methylation has been observed previously in acute
lymphoblastic leukemia (ALL), the patterns of differential methylation have not been …

Context.—A complete diagnosis of acute leukemia requires knowledge of clinical
information combined with morphologic evaluation, immunophenotyping and karyotype …

Outcome in multiple myeloma is highly variable and a better understanding of the factors
that influence disease biology is essential to understand and predict behavior in individual …

Purpose Molecular risk stratification of acute myeloid leukemia (AML) is largely based on
genetic markers. However, epigenetic changes, including DNA methylation, deregulate …

The discovery that the Ten-Eleven Translocation (TET) hydroxylases cause DNA
demethylation has fundamentally changed the notion of how DNA methylation is regulated …

Background Epigenetic alterations including DNA methylation and histone modifications are
the key factors in the differentiation of stem cells into different tissue subtypes. The …

The organization of the genome into functional units, such as enhancers and active or
repressed promoters, is associated with distinct patterns of DNA and histone modifications …

A hypoxic microenvironment leads to cancer progression and increases the metastatic
potential of cancer cells within tumors via epithelial-mesenchymal transition (EMT) and …