The renin-angiotensin-aldosterone system (RAAS) is a hormonal system that has a critical
role in maintaining the normotensive state and electrolyte balance of the organism. The …

Despite the clinical success and improvement in survival of cardiac transplantation in the
last 20 years, many patients develop chronic problems such as cardiac allograft …

Background The aim of the present study was to evaluate the potential protective effects of
six ginsenosides (Rb1, Rb2, Rc, Rd, Rg1, and Rg3) isolated from Panax ginseng against …

Tacrolimus (TAC), a calcineurin inhibitor (CNI), is clinically used as an immunosuppressive
agent in the transplant recipient; however, the use of TAC is greatly limited by its …

Tacrolimus is one of the most used and effective immunosuppressive agents currently
available in the clinic; however, its use is limited by nephrotoxicity, which is the main …

Background The kidneys are considered one of the most susceptible organs for adverse
drug effects, particularly in post-transplant conditions. Tacrolimus (FK506), a calcineurin …

Background Tacrolimus (Tac) and Cyclosporine A (CyA) calcineurin inhibitors (CNIs) are 2
effective immunosuppressants which are essential to prevent allograft rejection. Calcineurin …

Since chronic kidney disease due to diabetic nephropathy (DN) is becoming an ever larger
health burden worldwide, more effective therapies are desperately needed. In the present …

Background A traditional narrative review was performed to evaluate clinical studies that
have examined the clinical implications, risk factors, and prevention of calcineurin inhibitors …

Abstract Tacrolimus (FK506), a calcineurin inhibitor, is an effective immunosuppressive
agent mainly used to lower the risk of organ rejection after allogeneic organ transplant …