Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein
involved in the control of biological processes, such as cell proliferation, differentiation …

Members of the CCN family of matricellular proteins are crucial for embryonic development
and have important roles in inflammation, wound healing and injury repair in adulthood …

Fibrosis is responsible for chronic progressive kidney failure, which is present in a large
number of adults in the developed world. It is increasingly appreciated that acute kidney …

Interstitial fibrosis and hypoxia accelerate the progression of CKD, but clinical tools to
quantitate these factors in patients are lacking. Here, we evaluated the use of two magnetic …

Chronic kidney disease (CKD) is characterized by persistent inflammation and progressive
fibrosis, ultimately leading to end-stage renal disease. Although many studies have …

Background Connective tissue growth factor (CTGF) is widely thought to promote the
development of fibrosis in collaboration with transforming growth factor (TGF)-β; however …

The pathogenic mechanisms that lead to chronic kidney disease (CKD) converge on a
common pathway that results in progressive interstitial fibrosis, peritubular capillary loss with …

Background Glomerulonephritis, which causes inflammation in glomeruli, is a common
cause of end-stage renal failure. Severe and prolonged inflammation can damage glomeruli …

Connective tissue growth factor (CTGF) plays a critical role in angiotensin II (Ang II)–
mediated hypertensive nephropathy. The present study investigated the mechanisms and …

The mechanisms underlying fibrogenic responses after injury are not well understood.
Epithelial cell cycle arrest in G2/M after injury is a key checkpoint for determining wound …