In recent years the status of the inflammatory bowel diseases (IBDs) as canonical
autoimmune diseases has risen steadily with the recognition that these diseases are, at their …

There are now many experimental models of inflammatory bowel disease (IBD), most of
which are due to induced mutations in mice that result in an impaired homeostasis with the …

Background: Cytokines are essential mediators of the intestinal inflammation during active
episodes of inflammatory bowel disease (IBD). Interleukin (IL)-12 and IL-17 are potent …

Defensins represents an integral part of the innate immune system serving to ward off
potential pathogens and to protect the intestinal barrier from microbial encroachment. In …

Two related chronic inflammatory diseases, Crohn's disease and ulcerative colitis, are
together often referred to as inflammatory bowel disease (IBD). Current treatment options …

CD4+ regulatory T cells have been shown to prevent intestinal inflammation; however, it is
not known whether they act to prevent the priming of colitogenic T cells or actively control …

Chronic inflammation is strongly associated with approximately 1/5th of all human cancers.
Arising from combinations of factors such as environmental exposures, diet, inherited gene …

Active episodes of the inflammatory bowel diseases are associated with the infiltration of
large numbers of myeloid cells including neutrophils, monocytes, and macrophages. The …

Intestinal inflammation in inflammatory bowel disease (IBD) and experimental models of
colitis is characterized by a dysregulated intestinal immune response with elevated levels of …

Background & Aims: Recently, we demonstrated a proinflammatory effect of cytosin-
guanosin dinucleotide (CpG)-oligodeoxynucleotide (ODN) treatment in established dextran …