The dopaminergic system, and in particular the dopamine D2 receptor, has been implicated
in reward mechanisms. The net effect of neurotransmitter interaction at the mesolimbic brain …

Cocaine use continues to be a serious worldwide public health problem. Cocaine abuse is
associated with substantial morbidity and mortality. Cocaine overdose deaths are increasing …

scribí la primera edición de Fisiología de la Conducta hace más de un cuarto de siglo.
Cuando lo hice no podía imaginarme que algún día estaría escribiendo la octava edición …

Cocaine‐and amphetamine‐regulated transcript (CART) is a brain‐enriched mRNA with a
protein product (s) that is a candidate brain neurotransmitter. We have developed antisera to …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

Background: Both GABAergic and glutamatergic neurons appear to be important modulators
of the brain reward system and medications that affect GABA and glutamatergic …

Psychostimulants are a broadly defined class of drugs that stimulate the central and
peripheral nervous systems as their primary pharmacological effect. The abuse liability of …

A growing preclinical and clinical literature suggests that GABAB receptor agonists promote
abstinence and reduce the use of cocaine, heroin, alcohol and nicotine. The purpose of this …

Importance No medication has been established as an efficacious treatment for cocaine
dependence. We hypothesized that dual modulation of the mesocorticolimbic dopamine …

Laboratory models, both animal and human, have made enormous contributions to our
understanding of addiction. For addictive disorders, animal models have the great …