Before the coronavirus 2019 (COVID-19) pandemic began, antimicrobial resistance (AMR)
was among the top priorities for global public health. Already a complex challenge, AMR …

Infections caused by multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-
negative bacteria (GNB), including carbapenem-resistant (CR) Enterobacterales (CRE; …

Summary Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a global
threat. We therefore analysed the bacterial characteristics of CRKP infections and the …

The polymyxin antibiotics colistin (polymyxin E) and polymyxin B became available in the
1950s and thus did not undergo contemporary drug development procedures. Their clinical …

Carbapenems are considered as last-resort antibiotics for the treatment of infections caused
by multidrug-resistant Gram-negative bacteria. With the increasing use of carbapenems in …

Therapy of invasive infections due to multidrug-resistant Enterobacteriaceae (MDR-E) is
challenging, and some of the few active drugs are not available in many countries. For …

Modern medicine is threatened by the global rise of antibiotic resistance, especially among
Gram-negative bacteria. Metallo-β-lactamase (MBL) enzymes are a particular concern and …

Background Colistin–carbapenem combinations are synergistic in vitro against carbapenem-
resistant Gram-negative bacteria. We aimed to test whether combination therapy improves …

Background The efficacy of ceftazidime-avibactam—a cephalosporin–β-lactamase inhibitor
combination with in vitro activity against Klebsiella pneumoniae carbapenemase–producing …

Bloodstream infection (BSI) is defined by positive blood cultures in a patient with systemic
signs of infection and may be either secondary to a documented source or primary—that is …