Carbapenemases: the versatile β-lactamases

AM Queenan, K Bush - Clinical microbiology reviews, 2007 - Am Soc Microbiol
Carbapenemases are β-lactamases with versatile hydrolytic capacities. They have the ability
to hydrolyze penicillins, cephalosporins, monobactams, and carbapenems. Bacteria …

Metallo-β-lactamases: the quiet before the storm?

TR Walsh, MA Toleman, L Poirel… - Clinical microbiology …, 2005 - Am Soc Microbiol
The ascendancy of metallo-β-lactamases within the clinical sector, while not ubiquitous, has
nonetheless been dramatic; some reports indicate that nearly 30% of imipenem-resistant …

Virulence analysis and antibiotic resistance of Klebsiella pneumoniae isolates from hospitalised patients in Poland

B Kot, M Piechota, P Szweda, J Mitrus, J Wicha… - Scientific Reports, 2023 - nature.com
Klebsiella pneumoniae (KP) is a nosocomial pathogen causing difficult-to-treat infections.
The presence of virulence genes and antibiotic resistance of 109 KP isolates from …

Phenotypic detection of extended‐spectrum β‐lactamase production in Enterobacteriaceae: review and bench guide

L Drieux, F Brossier, W Sougakoff… - Clinical Microbiology …, 2008 - Wiley Online Library
Strains of Enterobacteriaceae producing an extended spectrum β‐lactamase have become
a concern in medical bacteriology as regards both antimicrobial treatment and infection …

Evaluation of the Hodge test and the imipenem-EDTA double-disk synergy test for differentiating metallo-β-lactamase-producing isolates of Pseudomonas spp. and …

K Lee, YS Lim, D Yong, JH Yum… - Journal of clinical …, 2003 - Am Soc Microbiol
Gram-negative bacilli with acquired metallo-β-lactamase (MBL) production have been
increasingly reported in some countries, necessitating their detection. The aim of this study …

[HTML][HTML] Acquired carbapenemases in Gram-negative bacterial pathogens: detection and surveillance issues

V Miriagou, G Cornaglia, M Edelstein, I Galani… - Clinical microbiology …, 2010 - Elsevier
Acquired carbapenemases are emerging resistance determinants in Gram-negative
pathogens, including Enterobacteriaceae, Pseudomonas aeruginosa and other Gram …

[HTML][HTML] Detection of carbapenemases in Enterobacteriaceae: a challenge for diagnostic microbiological laboratories

J Hrabák, E Chudáčková, CC Papagiannitsis - Clinical Microbiology and …, 2014 - Elsevier
Carbapenemase-producing bacteria have now spread all over the world. Infections caused
by those bacteria are difficult to treat. Therefore, there is an urgent need for accurate and fast …

Detection of β-lactamase-mediated resistance

DM Livermore, DFJ Brown - Journal of antimicrobial …, 2001 - academic.oup.com
Abstract β-Lactams are the most widely used antibiotics, and β-lactamases are the greatest
source of resistance to them. An understanding of β-lactamase detection and identification is …

Detection of Pseudomonas aeruginosa Producing Metallo-β-Lactamases in a Large Centralized Laboratory

JDD Pitout, DB Gregson, L Poirel… - Journal of clinical …, 2005 - Am Soc Microbiol
ABSTRACT Metallo-β-lactamases (MBLs) have been increasingly recognized from clinical
isolates worldwide, but the laboratory detection of these strains is not well defined. We report …

Antibiogram and genetic characterization of carbapenem-resistant gram-negative pathogens incriminated in healthcare-associated infections

RR Makharita, I El-Kholy, HF Hetta… - Infection and drug …, 2020 - Taylor & Francis
Purpose Carbapenems are considered the most efficient antibiotic used in the treatment of
nosocomial infections. Carbapenem-resistant Gram-negative rods are becoming a serious …