The introduction of selective COX-2 inhibitors (so-called 'coxibs') has demonstrated
tremendous commercial success due to their claimed lower potential of serious …

Psychiatric disorders such as schizophrenia and major depressive disorder were thought to
be caused by neurotransmitter abnormalities. Patients with these disorders often experience …

Lipopolysaccharide (LPS) administration may be used to induce an in vivo model for
neuroinflammation or neurodegeneration. We examined the regional distribution of …

Neuropsychiatric disorders, such as depression, bipolar disorder, schizophrenia, obsessive-
compulsive disorder, and neurodevelopmental disorders such as autism spectrum disorder …

Neuroinflammation is recognised as one of the potential mechanisms mediating the onset of
a broad range of psychiatric disorders and may contribute to nonresponsiveness to current …

Whether neuroinflammation leads to dopaminergic nigrostriatal system neurodegeneration
is controversial. We addressed this issue by inducing acute neuroinflammation in the …

Previous studies have demonstrated that pioglitazone, a peroxisome proliferator-activated
receptor gamma (PPARγ) agonist, inhibits ischemia-induced brain injury. The present study …

Neurodegeneration is a complex process, which leads to progressive brain damage due to
loss of neurons. Despite exhaustive research, the cause of neuronal loss in various …

During the postnatal period, the brain is highly sensitive to stress and inflammation, which
are hazardous to normal growth and development. There is increasing evidence that …

Background Although studies have reported an increased risk for mood disorders in
Hashimoto's thyroiditis (HT) patients even in the euthyroid state, the mechanisms involved …