Autophagy and endocytosis deliver unneeded cellular materials to lysosomes for
degradation. Beyond processing cellular waste, lysosomes release metabolites and ions …

Lysosomes serve as degradation hubs for the turnover of endocytic and autophagic cargos,
which is essential for neuron function and survival. Deficits in lysosome function result in …

Neurodegenerative diseases characterized by aberrant accumulation of undigested cellular
components represent unmet medical conditions for which the identification of actionable …

Neurons face the challenge of maintaining cellular homeostasis through lysosomal
degradation. While enzymatically active degradative lysosomes are enriched in the soma …

Niemann-Pick disease type C (NPC) is a neurodegenerative lysosomal storage disorder
characterized by lipid accumulation in endolysosomes. An early pathologic hallmark is …

Abstract Background Haploinsufficiency in the Gaucher disease GBA gene, which encodes
the lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for …

The mechanisms of autophagy have been related to Alzheimer's disease (AD) pathogenesis
by the endosomal‐lysosomal system, having a critical function in forming amyloid‐β (Aβ) …

Selective neuron loss in discrete brain regions is a hallmark of various neurodegenerative
disorders, although the mechanisms responsible for this regional vulnerability of neurons …

Parkinson's disease (PD) is the second most common age-related neurodegenerative
disorder after Alzheimer's disease. Increasing evidence highlights the role of age-related …

Lysosomal storage diseases (LSDs) are a group of rare diseases in which the function of the
lysosome is disrupted by the accumulation of macromolecules. The complexity underlying …