Large bone defects resulting from musculoskeletal tumours, infections, or trauma are often
unable to heal spontaneously. The challenge for surgeons is to avoid amputation, and …

Critical-sized bone defects are defined as those that will not heal spontaneously within a
patient's lifetime. Current treatment options include vascularized bone grafts, distraction …

Disclosure: The authors indicated that no external funding was received for any aspect of
this work. On the Disclosure of Potential Conflicts of Interest forms, which are provided with …

Masquelet's induced membrane technique (MIMT) is a relatively new, two‐stage surgical
procedure to reconstruct segmental bone defects. First performed by Dr. Masquelet in the …

Bone reconstruction within a critical‐sized defect remains a real challenge in orthopedic
surgery. The Masquelet technique is an innovative, two‐step therapeutic approach for bone …

Massive segmental bone defects (SBD) are mostly treated by removing the fibula and
transplanting it complete with blood supply. While revolutionary 50 years ago, this remains …

Bone defects may impede normal biomechanics and the structural stability of bone as an
organ. In many cases, the correction of bone defects requires extensive surgical intervention …

Because of its simplicity, reliability, and replicability, the Masquelet induced membrane
technique (IMT) has become one of the preferred methods for critical bone defect …

Purpose The Masquelet technique is a procedure increasingly utilized for addressing
segmental bone defects. The technique involves staged procedures consisting of bone …

Total flavonoids of Rhizoma drynariae (TFRD), a Chinese medicine, is widely used in the
treatment of fracture, bone defect, osteoporosis and other orthopedic diseases, and has …