Proteases form one of the largest and more important groups of enzymes. They selectively
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …

The rapid outbreak of coronavirus disease 2019 (COVID-19) has demonstrated the need for
development of new vaccine candidates and therapeutic drugs to fight against the …

Porcine epidemic diarrhea virus (PEDV) causes an emerging and re-emerging coronavirus
disease characterized by vomiting, acute diarrhea, dehydration, and up to 100% mortality in …

Coronaviruses can infect a variety of animals including poultry, livestock, and humans and
are currently classified into three groups. The interspecies transmissions of coronaviruses …

ABSTRACT Nonstructural protein 15 (Nsp15) encoded by coronavirus (CoV) is a nidoviral
uridylate-specific endoribonuclease (NendoU) that plays an essential role in the life cycle of …

In the mid-sixties of the previous century, the first two human coronaviruses (HCoV) were
identified: HCoV-229E and HCoV-OC43 (29, 50, 70). These two human coronaviruses were …

Background: The world has been unprecedentedly hit by a global pandemic which broke the
record of deadly pandemics that faced humanity ever since its existence. Even kids are well …

ABSTRACT The 3C-like proteinase (3CLpro) of severe acute respiratory syndrome-
associated coronavirus (SARS-CoV) is one of the most promising targets for anti-SARS-CoV …

The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and
Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 has generated …

There is an urgent need to develop effective treatments for coronavirus disease 2019
(COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS …