[HTML][HTML] Early-life exposure to widespread environmental toxicants and health risk: a focus on the immune and respiratory systems

J Cao, X Xu, MN Hylkema, EY Zeng, PD Sly… - Annals of global …, 2016 - Elsevier
Evidence has accumulated that exposure to widespread environmental toxicants, such as
heavy metals, persistent organic pollutants, and tobacco smoke adversely affect fetal …

Epigenetics and the developmental origins of lung disease

LA Joss-Moore, RH Lane, KH Albertine - The Lung, 2014 - Elsevier
Environmental disruptions during the course of lung development produce long-term
changes in lung structure and function that predispose towards adult lung disease, a …

The role of nicotine in the effects of maternal smoking during pregnancy on lung development and childhood respiratory disease. Implications for dangers of e …

ER Spindel, CT McEvoy - American journal of respiratory and critical …, 2016 - atsjournals.org
Use of e-cigarettes, especially among the young, is increasing at near-exponential rates.
This is coupled with a perception that e-cigarettes are safe and with unlimited advertising …

[HTML][HTML] Environmental tobacco smoke and children's health

SH Hwang, JH Hwang, JS Moon… - Korean journal of …, 2012 - ncbi.nlm.nih.gov
Passive exposure to tobacco smoke significantly contributes to morbidity and mortality in
children. Children, in particular, seem to be the most susceptible population to the harmful …

Alterations in DNA methylation and airway hyperreactivity in response to in utero exposure to environmental tobacco smoke

JW Lee, Z Jaffar, KE Pinkerton, V Porter… - Inhalation …, 2015 - Taylor & Francis
Growing evidence indicates that prenatal exposure to maternal smoking is a risk factor for
the development of asthma in children. However, the effects of prenatal environmental …

[HTML][HTML] Respiratory system diseases of nonhuman primates

LJ Lowenstine, KG Osborn - Nonhuman primates in biomedical …, 2012 - ncbi.nlm.nih.gov
The respiratory system is one of the most commonly affected systems in reports describing
nonhuman primate disease, pathology, and/or clinical management. Such general papers …

Small particles disrupt postnatal airway development

DY Lee, C Wallis, AS Wexler… - Journal of Applied …, 2010 - journals.physiology.org
Increasing numbers of epidemiologic studies associate air pollution exposure in children
with decreased lung function development. The objective of this study was to examine the …

Disruption of tracheobronchial airway growth following postnatal exposure to ozone and ultrafine particles

DY Lee, C Wallis, LS Van Winkle… - Inhalation toxicology, 2011 - Taylor & Francis
This study examined airway structure changes in adult rats after a long recovery period due
to sub-chronic juvenile exposure to ozone and ultrafine particles that have a high organic …

Postnatal growth of tracheobronchial airways of Sprague–Dawley rats

DY Lee, PK Srirama, C Wallis, AS Wexler - Journal of anatomy, 2011 - Wiley Online Library
Rats are widely used for the studies of pulmonary toxicology in both juveniles and adults. To
facilitate such studies, investigators have developed models of lung architecture based on …

[HTML][HTML] Detecting alterations in pulmonary airway development with airway-by-airway comparison

DY Lee, N Willits, AS Wexler - Annals of biomedical engineering, 2011 - Springer
Neonatal and postnatal exposures to air pollutants have adverse effects on lung
development resulting in airway structure changes. Usually, generation-averaged analysis …