Post-translational modifications of G Protein–Coupled receptors control cellular signaling dynamics in space and time
G protein–coupled receptors (GPCRs) are a large family comprising> 800 signaling
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …
[HTML][HTML] A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
(SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has …
[HTML][HTML] Structures of the TMC-1 complex illuminate mechanosensory transduction
H Jeong, S Clark, A Goehring… - Nature, 2022 - nature.com
The initial step in the sensory transduction pathway underpinning hearing and balance in
mammals involves the conversion of force into the gating of a mechanosensory transduction …
mammals involves the conversion of force into the gating of a mechanosensory transduction …
Loss of pollen‐specific phospholipase NOT LIKE DAD triggers gynogenesis in maize
LM Gilles, A Khaled, JB Laffaire, S Chaignon… - The EMBO …, 2017 - embopress.org
Gynogenesis is an asexual mode of reproduction common to animals and plants, in which
stimuli from the sperm cell trigger the development of the unfertilized egg cell into a haploid …
stimuli from the sperm cell trigger the development of the unfertilized egg cell into a haploid …
Time-resolved proteomics profiling of the ciliary Hedgehog response
EA May, M Kalocsay, IG D'auriac, PS Schuster… - Journal of Cell …, 2021 - rupress.org
The primary cilium is a signaling compartment that interprets Hedgehog signals through
changes of its protein, lipid, and second messenger compositions. Here, we combine …
changes of its protein, lipid, and second messenger compositions. Here, we combine …
SPalmitoylC-PseAAC: A sequence-based model developed via Chou's 5-steps rule and general PseAAC for identifying S-palmitoylation sites in proteins
S-Palmitoylation is a uniquely reversible and biologically important post-translational
modification as it plays an essential role in a variety of cellular processes including signal …
modification as it plays an essential role in a variety of cellular processes including signal …
GPS-Palm: a deep learning-based graphic presentation system for the prediction of S-palmitoylation sites in proteins
As an important reversible lipid modification, S-palmitoylation mainly occurs at specific
cysteine residues in proteins, participates in regulating various biological processes and is …
cysteine residues in proteins, participates in regulating various biological processes and is …
The IQD family of calmodulin-binding proteins links calcium signaling to microtubules, membrane subdomains, and the nucleus
K Bürstenbinder, B Möller, R Plötner, G Stamm… - Plant …, 2017 - academic.oup.com
Abstract Calcium (Ca2+) signaling and dynamic reorganization of the cytoskeleton are
essential processes for the coordination and control of plant cell shape and cell growth …
essential processes for the coordination and control of plant cell shape and cell growth …
Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy
RS Møller, S Weckhuysen, M Chipaux… - Neurology …, 2016 - AAN Enterprises
Objective: To assess the prevalence of somatic MTOR mutations in focal cortical dysplasia
(FCD) and of germline MTOR mutations in a broad range of epilepsies. Methods: We …
(FCD) and of germline MTOR mutations in a broad range of epilepsies. Methods: We …