[HTML][HTML] Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

The immunopathology of sepsis and potential therapeutic targets

T van der Poll, FL van de Veerdonk… - Nature Reviews …, 2017 - nature.com
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

[HTML][HTML] Sepsis and septic shock

RS Hotchkiss, LL Moldawer, SM Opal… - Nature reviews Disease …, 2016 - nature.com
For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

Innovative and rapid antimicrobial susceptibility testing systems

A van Belkum, CAD Burnham, JWA Rossen… - Nature Reviews …, 2020 - nature.com
Antimicrobial resistance (AMR) is a major threat to human health worldwide, and the rapid
detection and quantification of resistance, combined with antimicrobial stewardship, are key …

[HTML][HTML] Futuristic non-antibiotic therapies to combat antibiotic resistance: A review

M Kumar, DK Sarma, S Shubham, M Kumawat… - Frontiers in …, 2021 - frontiersin.org
The looming problem of resistance to antibiotics in microorganisms is a global health
concern. The drug-resistant microorganisms originating from anthropogenic sources and …

Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management

S Thamphiwatana, P Angsantikul… - Proceedings of the …, 2017 - National Acad Sciences
Sepsis, resulting from uncontrolled inflammatory responses to bacterial infections, continues
to cause high morbidity and mortality worldwide. Currently, effective sepsis treatments are …

An enzyme‐mimicking single‐atom catalyst as an efficient multiple reactive oxygen and nitrogen species scavenger for sepsis management

F Cao, L Zhang, Y You, L Zheng, J Ren… - Angewandte …, 2020 - Wiley Online Library
Sepsis, characterized by immoderate production of multiple reactive oxygen and nitrogen
species (RONS), causes high morbidity and mortality. Despite progress made with …

Microfluidic devices: a tool for nanoparticle synthesis and performance evaluation

S Gimondi, H Ferreira, RL Reis, NM Neves - ACS nano, 2023 - ACS Publications
The use of nanoparticles (NPs) in nanomedicine holds great promise for the treatment of
diseases for which conventional therapies present serious limitations. Additionally, NPs can …

[HTML][HTML] based synthetic gene networks

K Pardee, AA Green, T Ferrante, DE Cameron… - Cell, 2014 - cell.com
Synthetic gene networks have wide-ranging uses in reprogramming and rewiring
organisms. To date, there has not been a way to harness the vast potential of these networks …

A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

DC Leslie, A Waterhouse, JB Berthet, TM Valentin… - Nature …, 2014 - nature.com
Thrombosis and biofouling of extracorporeal circuits and indwelling medical devices cause
significant morbidity and mortality worldwide. We apply a bioinspired, omniphobic coating to …