In the course of examining the effect of electric fields on the growth of Escherichia coli cells,
a biological activity of platinum compounds was uncovered that led to the development of …

BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

Following the serendipitous discovery of the anticancer activity of cisplatin over 50 years
ago, a deep understanding of the chemical and biochemical transformations giving rise to its …

Thirty years after the onset of the first clinical studies with cisplatin, the development of
antineoplastic platinum drugs continues to be a productive field of research. This article …

Several mutations in nuclear genes encoding for mitochondrial components have been
associated with an increased cancer risk or are even causative, eg succinate …

An analog of the anticancer drug cisplatin (mtPt) was delivered to mitochondria of human
cells using a peptide specifically targeting this organelle. mtPt induces apoptosis without …

Chemotherapy has significantly increased the number of cancer survivors. However,
chemotherapy itself carries various adverse effects that limit the efficacy of treatment and …

Purpose: Cisplatin adducts to nuclear DNA (nDNA) are felt to be the molecular lesions that
trigger apoptosis, but the mechanism linking nDNA adduct formation and cell death is …

Cisplatin is a chemotherapeutic drug widely used against a variety of cancers. Its clinical
utility is severely limited by its toxicity, which mainly affects, but is not limited to, the inner ear …

Oxaliplatin is a clinical anticancer drug with a pharmacological profile distinct from that of
cisplatin. Our studies compared site-and region-specificity of lesions induced by oxaliplatin …