[HTML][HTML] A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics
Neurodegenerative disorders are primarily characterized by neuron loss. The most common
neurodegenerative disorders include Alzheimer's and Parkinson's disease. Although there …
neurodegenerative disorders include Alzheimer's and Parkinson's disease. Although there …
Neuroinflammation pathways: a general review
T Shabab, R Khanabdali… - International Journal …, 2017 - Taylor & Francis
Activated microglial cells play an important role in immune and inflammatory responses in
central nervous system and neurodegenerative diseases. Many pro-apoptotic pathways are …
central nervous system and neurodegenerative diseases. Many pro-apoptotic pathways are …
[HTML][HTML] Brain and peripheral atypical inflammatory mediators potentiate neuroinflammation and neurodegeneration
D Kempuraj, R Thangavel, GP Selvakumar… - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammatory response is primarily a protective mechanism in the brain. However,
excessive and chronic inflammatory responses can lead to deleterious effects involving …
excessive and chronic inflammatory responses can lead to deleterious effects involving …
Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade
C Oyinbo - Acta neurobiologiae experimentalis, 2011 - ane.pl
The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary
mechanisms of injury. Though both mechanisms are involved in the neurological …
mechanisms of injury. Though both mechanisms are involved in the neurological …
Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a …
B Leonard, M Maes - Neuroscience & Biobehavioral Reviews, 2012 - Elsevier
This paper reviews that cell-mediated-immune (CMI) activation and inflammation contribute
to depressive symptoms, including anhedonia; anxiety-like behaviors; fatigue and somatic …
to depressive symptoms, including anhedonia; anxiety-like behaviors; fatigue and somatic …
Microglia in neurodegenerative disease
VH Perry, JAR Nicoll, C Holmes - Nature Reviews Neurology, 2010 - nature.com
Microglia, the resident macrophages of the CNS, are exquisitely sensitive to brain injury and
disease, altering their morphology and phenotype to adopt a so-called activated state in …
disease, altering their morphology and phenotype to adopt a so-called activated state in …
Cocoa and chocolate in human health and disease
Cocoa contains more phenolic antioxidants than most foods. Flavonoids, including catechin,
epicatechin, and procyanidins predominate in antioxidant activity. The tricyclic structure of …
epicatechin, and procyanidins predominate in antioxidant activity. The tricyclic structure of …
Astrocyte–neuron metabolic relationships: for better and for worse
I Allaman, M Bélanger, PJ Magistretti - Trends in neurosciences, 2011 - cell.com
In recent years, previously unsuspected roles of astrocytes have been revealed, largely
owing to the development of new tools enabling their selective study in situ. These exciting …
owing to the development of new tools enabling their selective study in situ. These exciting …
Caspase signalling controls microglia activation and neurotoxicity
Activation of microglia and inflammation-mediated neurotoxicity are suggested to play a
decisive role in the pathogenesis of several neurodegenerative disorders. Activated …
decisive role in the pathogenesis of several neurodegenerative disorders. Activated …
Recent update on basic mechanisms of spinal cord injury
Spinal cord injury (SCI) is a life-shattering neurological condition that affects between
250,000 and 500,000 individuals each year with an estimated two to three million people …
250,000 and 500,000 individuals each year with an estimated two to three million people …