The increasing life expectancy of humans has led to a growing numbers of patients with
chronic diseases and end-stage organ failure. Transplantation is an effective approach for …

The shortage of organs and cells from deceased individuals continues to restrict
allotransplantation. Pigs could provide an alternative source of tissue and cells but the …

There is a critical shortage in the number of deceased human organs that become available
for the purposes of clinical transplantation. This problem might be resolved by the …

Cross-species transplantation (xenotransplantation) offers the prospect of an unlimited
supply of organs and cells for clinical transplantation, thus resolving the critical shortage of …

The immunologic barriers to successful xenotransplantation are related to the presence of
natural anti‐pig antibodies in humans and non‐human primates that bind to antigens …

Transgenic pigs are promising donor organisms for xenotransplantation as they share many
anatomical and physiological characteristics with humans. The most profound barrier to pig …

For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

Genetically modified swine hold great promise in the fields of agriculture and medicine.
Currently, these swine are being used to optimize production of quality meat, to improve our …

To bridge the gap between organ demand and supply, xenotransplantation has long been
considered as a realistic option for end-stage organ failure. Early this year this promise …

Background The pig‐to‐non‐human primate model is the standard choice for in vivo studies
of organ and cell xenotransplantation. In 1998, Lambrigts and his colleagues surveyed the …