Human adenoviruses (HAdVs) can cause mild respiratory, gastrointestinal, urogenital and
ocular disease. Knowledge about HAdVs has been expanding for more than five decades …

DNA viruses promote cell cycle progression, stimulate unscheduled DNA synthesis, and
present the cell with an extraordinary amount of exogenous DNA. These insults elicit …

Persistent viruses cause chronic disease, and threaten the lives of immunosuppressed
individuals. Here, we elucidate a mechanism supporting the persistence of human …

Human adenovirus commonly causes infections of respiratory, gastrointestinal,
genitourinary, and ocular surface mucosae. Although most adenovirus eye infections are …

The adenoviral protein E3-14.7 K (14.7 K) is an inhibitor of TNF-induced apoptosis, but the
molecular mechanism underlying this protective effect has not yet been explained …

The story of p53 and how we came to understand it is punctuated by fundamental insights
into the essence of cancer. In the decades since its discovery, p53 has been shown to be …

ZC3H11A is a cellular protein associated with the transcription export (TREX) complex that
is induced during heat-shock. Several nuclear-replicating viruses exploit the mRNA export …

Human adenoviruses (Ads) generally cause mild self-limiting infections but can lead to
serious disease and even be fatal in high-risk individuals, underscoring the importance of …

ABSTRACT Human adenovirus serotype 5 (AdH5) vector vaccines elicit strong immune
responses to the encoded antigen and have been used in various disease models. We …

Niemann–Pick disease type C (NPC) is caused by mutations in NPC1 or NPC2, which
coordinate egress of low-density-lipoprotein (LDL)-cholesterol from late endosomes. We …