Systemic effects of chronic obstructive pulmonary disease

AGN Agusti, A Noguera, J Sauleda… - European …, 2003 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is characterised by an inappropriate/
excessive inflammatory response of the lungs to respiratory pollutants, mainly tobacco …

Oxidative stress and redox regulation of lung inflammation in COPD

I Rahman, IM Adcock - European respiratory journal, 2006 - Eur Respiratory Soc
Reactive oxygen species, either directly or via the formation of lipid peroxidation products,
may play a role in enhancing inflammation through the activation of stress kinases (c-Jun …

[HTML][HTML] Smoking and Chronic Obstructive Pulmonary Disease (COPD). Parallel Epidemics of the 21st Century

R Laniado-Laborín - International journal of environmental research and …, 2009 - mdpi.com
One hundred million deaths were caused by tobacco in the 20th century, and it is estimated
that there will be up to one billion deaths attributed to tobacco use in the 21st century …

Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy

P Kirkham, I Rahman - Pharmacology & therapeutics, 2006 - Elsevier
Asthma and chronic obstructive pulmonary disease (COPD) are inflammatory lung diseases
that are characterized by systemic and chronic localized inflammation and oxidative stress …

[HTML][HTML] Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase–and cathepsin-dependent emphysema

T Zheng, Z Zhu, Z Wang, RJ Homer… - The Journal of …, 2000 - Am Soc Clin Investig
Cigarette smoke exposure is the major cause of chronic obstructive pulmonary disease
(COPD). However, only a minority of smokers develop significant COPD, and patients with …

Chronic obstructive pulmonary disease due to occupational exposure to silica dust: a review of epidemiological and pathological evidence

E Hnizdo, V Vallyathan - Occupational and environmental medicine, 2003 - oem.bmj.com
Occupational exposure is an important risk factor for chronic obstructive pulmonary disease
(COPD), and silica dust is one of the most important occupational respiratory toxins …

4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease

I Rahman, AAM van Schadewijk… - American journal of …, 2002 - atsjournals.org
Cigarette smoking results in oxidative stress and inflammation in the lungs, which are
involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). 4-Hydroxy-2 …

Roflumilast: a review of its use in the treatment of COPD

JA Wedzicha, PM Calverley… - International journal of …, 2016 - Taylor & Francis
COPD is a progressive condition involving chronic inflammation and parenchymal
destruction with resulting airflow limitation. COPD is associated with worsening airflow …

Short-term exposure to high ambient air pollution increases airway inflammation and respiratory symptoms in chronic obstructive pulmonary disease patients in …

S Wu, Y Ni, H Li, L Pan, D Yang, AA Baccarelli… - Environment …, 2016 - Elsevier
Background Few studies have investigated the short-term respiratory effects of ambient air
pollution in chronic obstructive pulmonary disease (COPD) patients in the context of high …

Cigarette smoking and inflammation revisited

O Rom, K Avezov, D Aizenbud, AZ Reznick - Respiratory physiology & …, 2013 - Elsevier
Despite the significant health risks resulting from tobacco use, the prevalence of smokers
worldwide remains high. Cigarette smoking is one of the major sources of toxic chemical …