In agonising, crippling pain from lung cancer, Mr S came to the palliative care service in
Calicut, Kerala, from an adjoining district a couple of hours away by bus. His body language …

Importance Primary care clinicians find managing chronic pain challenging. Evidence of
long-term efficacy of opioids for chronic pain is limited. Opioid use is associated with serious …

Background: Prescription opioid–related overdose deaths increased sharply during 1999–
2010 in the United States in parallel with increased opioid prescribing. CDC assessed …

Importance Chronic opioid use imposes a substantial burden in terms of morbidity and
economic costs. Whether opioid-naive patients undergoing surgery are at increased risk for …

Public health authorities have described, with growing alarm, an unprecedented increase in
morbidity and mortality associated with use of opioid pain relievers (OPRs). Efforts to …

Importance Opioid analgesic overdose mortality continues to rise in the United States, driven
by increases in prescribing for chronic pain. Because chronic pain is a major indication for …

Opioid use for pain management has dramatically increased, with little assessment of
potential pathophysiological consequences for the primary pain condition. Here, a short …

The relationships between the initial opioid prescription characteristics and pain etiology
with the probability of opioid discontinuation were explored in this retrospective cohort study …

Background Drug overdose deaths have been rising since the early 1990s and is the
leading cause of injury death in the United States. Overdose from prescription opioids …

The past few decades have seen an alarming rise in opioid use in the United States, and the
negative consequences from diversion of opioids for nontherapeutic use are dramatically …