The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

Ceramides are a heterogeneous group of bioactive membrane sphingolipids that play
specialized regulatory roles in cellular metabolism depending on their characteristic fatty …

Until menopause, women have a lower propensity to develop metabolic diseases than men,
suggestive of a protective role for sex hormones. Although a functional synergy between …

Current pharmacological therapies for treating obesity are of limited efficacy. Genetic
ablation or loss of function of AMP-activated protein kinase alpha 1 (AMPKα1) in …

Ceramide accumulation is a hallmark in the manifestation of numerous obesity-related
diseases, such as type 2 diabetes mellitus and atherosclerosis. Until the early 2000s …

Over the last two decades, it has become evident that estrogens preserve the integrity of
energy homeostasis at central and peripheral levels. Estrogen deficiency, such as that …

Endocrine disrupting chemicals (EDCs), a heterogeneous group of exogenous chemicals
that can interfere with any aspect of endogenous hormones, represent an emerging global …

Brown adipose tissue (BAT), a thermoregulatory organ known to promote energy
expenditure, has been extensively studied as a potential avenue to combat obesity …

Childhood obesity, especially in girls, is frequently bound to earlier puberty, which is linked
to higher disease burden later in life. The mechanisms underlying this association remain …

In the midst of an obesity epidemic, the promotion of brown adipose tissue (BAT) function
and the browning of white adipose tissue (WAT) have emerged as promising therapeutic …