B cell activation and differentiation yields plasma cells with high affinity antibodies to a given
antigen in a time-frame that allows for host protection. Although the end product is most …

Multiple myeloma is a neoplasm of terminally differentiated B cells (plasma cells) in which
chromosome translocations frequently place oncogenes under the control of …

Chromosomal fragile sites are specific loci that preferentially exhibit gaps and breaks on
metaphase chromosomes following partial inhibition of DNA synthesis. Their discovery has …

DNA replication is a fundamental process of the cell that ensures accurate duplication of the
genetic information and subsequent transfer to daughter cells. Various pertubations …

Conditions that partially inhibit DNA replication induce expression of common fragile sites.
These sites form gaps and breaks on metaphase chromosomes and are deleted and …

The WWOX gene is a recently cloned tumor suppressor gene that spans the FRA16D fragile
region. Wwox protein contains two WW domains that are generally known to mediate protein …

The WW domain-containing oxidoreductase (WWOX) spans the second most common
fragile site of the human genome, FRA16D, located at 16q23, and its expression is altered in …

The cloning and characterization of the common fragile site (CFS) FRA6E (6q26) identified
Parkin, the gene involved in the pathogenesis of many cases of juvenile, early-onset and …

Aberrant activation of tyrosine kinases is linked causally to human cancers. Activated Cdc42-
associated kinase (Ack1), an intracellular tyrosine kinase, has primarily been studied for its …

Common fragile sites (CFSs) are large regions of profound genomic instability found in all
individuals. They are biologically significant due to their role in a number of genomic …