Introduction: Despite more that 60 years of clinical experience, the effective use of lithium for
the treatment of mood disorder, in particular bipolarity, is in danger of becoming obsolete. In …

Background Pharmacological augmentation is a recommended strategy for patients with
treatment-resistant depression. A range of guidelines provide advice on treatment selection …

After a single dose, lithium, usually given as carbonate, reaches a peak plasma
concentration at 1.0–2.0 hours for standard-release dosage forms, and 4–5 hours for …

Neurodegeneration is a pathological process characterized by progressive neuronal
impairment, dysfunction, and loss due to mitochondrial dysfunction, oxidative stress …

Lithium preparations have been successfully used to treat bipolar disorder (BD), and remain
the best established long-term treatment for the disorder. In fact, lithium is a cornerstone of …

Lithium is a commonly prescribed treatment for bipolar disorder. Many early studies on
which its use has been historically based no longer meet current research standards. A …

Bipolar disorder is a recurrent chronic illness distinguished by periods of mania and
depression. Lithium has been used for about 60 years as a 'mood stabilizer'for bipolar …

Lithium has been a gold standard in the treatment of bipolar disorder (BD) for several
decades. Despite a general reduction in the use of lithium over the past several years, it is …

Objective: Despite several decades of research, there is still uncertainty regarding the
optimal lithium dosage regimen associated with a decreased risk of renal effects, such as …

Objective: The goal of this survey study was to assess specific aspects of lithium therapy for
bipolar disorder, including psychiatrists' prescribing practices, understanding of therapeutic …