[HTML][HTML] Human organs-on-chips for disease modelling, drug development and personalized medicine
DE Ingber - Nature Reviews Genetics, 2022 - nature.com
The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …
[HTML][HTML] A guide to the organ-on-a-chip
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …
[HTML][HTML] A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics
The rapid repurposing of antivirals is particularly pressing during pandemics. However,
rapid assays for assessing candidate drugs typically involve in vitro screens and cell lines …
rapid assays for assessing candidate drugs typically involve in vitro screens and cell lines …
[HTML][HTML] Performance assessment and economic analysis of a human Liver-Chip for predictive toxicology
L Ewart, A Apostolou, SA Briggs, CV Carman… - Communications …, 2022 - nature.com
Background Conventional preclinical models often miss drug toxicities, meaning the harm
these drugs pose to humans is only realized in clinical trials or when they make it to market …
these drugs pose to humans is only realized in clinical trials or when they make it to market …
[HTML][HTML] A role for microfluidic systems in precision medicine
JM Ayuso, M Virumbrales-Muñoz, JM Lang… - Nature …, 2022 - nature.com
Precision oncology continues to challenge the “one-size-fits-all” dogma. Under the precision
oncology banner, cancer patients are screened for molecular tumor alterations that predict …
oncology banner, cancer patients are screened for molecular tumor alterations that predict …
[HTML][HTML] Organoid and spheroid tumor models: Techniques and applications
S Gunti, ATK Hoke, KP Vu, NR London Jr - Cancers, 2021 - mdpi.com
Simple Summary Cell cultures can be carried out in three dimensions (3D). Organoids and
spheroids are different 3D cell culture models that can be cultured with different techniques …
spheroids are different 3D cell culture models that can be cultured with different techniques …
[HTML][HTML] Multiorgan-on-a-chip: a systemic approach to model and decipher inter-organ communication
N Picollet-D'hahan, A Zuchowska, I Lemeunier… - Trends in …, 2021 - cell.com
Multiorgan-on-a-chip (multi-OoC) platforms have great potential to redefine the way in which
human health research is conducted. After briefly reviewing the need for comprehensive …
human health research is conducted. After briefly reviewing the need for comprehensive …
Is it time for reviewer 3 to request human organ chip experiments instead of animal validation studies?
DE Ingber - Advanced Science, 2020 - Wiley Online Library
For the past century, experimental data obtained from animal studies have been required by
reviewers of scientific articles and grant applications to validate the physiological relevance …
reviewers of scientific articles and grant applications to validate the physiological relevance …
Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips
Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in
animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD …
animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD …
Engineering vascularized organoid-on-a-chip models
VS Shirure, CCW Hughes… - Annual Review of …, 2021 - annualreviews.org
Recreating human organ–level function in vitro is a rapidly evolving field that integrates
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …
tissue engineering, stem cell biology, and microfluidic technology to produce 3D organoids …