Human ether-a-go-go-related gene (hERG) channel blockade by small molecules is a big
concern during drug development in the pharmaceutical industry. Failure or inhibition of …

Long non-coding RNA (lncRNA) and microRNA (miRNA) are two typical types of non-coding
RNAs (ncRNAs), their interaction plays an important regulatory role in many biological …

Metabolism is the process by which an organism continuously replaces old substances with
new substances. It plays an important role in maintaining human life, body growth and …

Metabolism refers to a series of orderly chemical reactions used to maintain life activities in
organisms. In healthy individuals, metabolism remains within a normal range. However …

In recent years, single-cell RNA sequencing (scRNA-seq) has emerged as a powerful
technique for investigating cellular heterogeneity and structure. However, analyzing scRNA …

Increasing evidences show that the occurrence of human complex diseases is closely
related to microRNA (miRNA) variation and imbalance. For this reason, predicting disease …

The carcinogenicity of drugs can have a serious impact on human health, so carcinogenicity
testing of new compounds is very necessary before being put on the market. Currently, many …

With the rapid advancement in sequencing technologies, the concept of omics has
revolutionized our understanding of cellular behaviors. Conventional omics investigation …

Abstract Background Protein-protein interactions (PPIs) dominate intracellular molecules to
perform a series of tasks such as transcriptional regulation, information transduction, and …

Many biological studies show that the mutation and abnormal expression of microRNAs
(miRNAs) could cause a variety of diseases. As an important biomarker for disease …