[HTML][HTML] Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects

TM Uddin, AJ Chakraborty, A Khusro… - Journal of infection and …, 2021 - Elsevier
Antibiotics have been used to cure bacterial infections for more than 70 years, and these low-
molecular-weight bioactive agents have also been used for a variety of other medicinal …

[HTML][HTML] Review of COVID-19 testing and diagnostic methods

O Filchakova, D Dossym, A Ilyas, T Kuanysheva… - Talanta, 2022 - Elsevier
More than six billion tests for COVID-19 has been already performed in the world. The
testing for SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) virus and …

Current applications and future perspective of CRISPR/Cas9 gene editing in cancer

SW Wang, C Gao, YM Zheng, L Yi, JC Lu, XY Huang… - Molecular cancer, 2022 - Springer
Clustered regularly interspaced short palindromic repeats (CRISPR) system provides
adaptive immunity against plasmids and phages in prokaryotes. This system inspires the …

Programmable RNA targeting with the single-protein CRISPR effector Cas7-11

A Özcan, R Krajeski, E Ioannidi, B Lee, A Gardner… - Nature, 2021 - nature.com
CRISPR–Cas interference is mediated by Cas effector nucleases that are either components
of multisubunit complexes—in class 1 CRISPR–Cas systems—or domains of a single …

RNA drugs and RNA targets for small molecules: principles, progress, and challenges

AM Yu, YH Choi, MJ Tu - Pharmacological reviews, 2020 - ASPET
RNA-based therapies, including RNA molecules as drugs and RNA-targeted small
molecules, offer unique opportunities to expand the range of therapeutic targets. Various …

The CRISPR tool kit for genome editing and beyond

M Adli - Nature communications, 2018 - nature.com
CRISPR is becoming an indispensable tool in biological research. Once known as the
bacterial immune system against invading viruses, the programmable capacity of the Cas9 …

[PDF][PDF] The biology of CRISPR-Cas: backward and forward

F Hille, H Richter, SP Wong, M Bratovič, S Ressel… - Cell, 2018 - cell.com
In bacteria and archaea, clustered regularly interspaced short palindromic repeats
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …

Novel CRISPR–Cas systems: an updated review of the current achievements, applications, and future research perspectives

S Nidhi, U Anand, P Oleksak, P Tripathi, JA Lal… - International journal of …, 2021 - mdpi.com
According to Darwin's theory, endless evolution leads to a revolution. One such example is
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …

Origins and evolution of CRISPR-Cas systems

EV Koonin, KS Makarova - Philosophical Transactions of …, 2019 - royalsocietypublishing.org
CRISPR-Cas, the bacterial and archaeal adaptive immunity systems, encompass a complex
machinery that integrates fragments of foreign nucleic acids, mostly from mobile genetic …

CRISPR‐Cas‐based detection for food safety problems: Current status, challenges, and opportunities

Y Li, S Man, S Ye, G Liu, L Ma - Comprehensive Reviews in …, 2022 - Wiley Online Library
Food safety is one of the biggest public issues occurring around the world. Microbiological,
chemical, and physical hazards can lead to food safety issues, which may occur at all stages …