[HTML][HTML] The gut microbiome in Alzheimer's disease: what we know and what remains to be explored

S Chandra, SS Sisodia, RJ Vassar - Molecular neurodegeneration, 2023 - Springer
Abstract Alzheimer's disease (AD), the most common cause of dementia, results in a
sustained decline in cognition. There are currently few effective disease modifying therapies …

[HTML][HTML] Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

A Więckowska-Gacek, A Mietelska-Porowska… - Ageing research …, 2021 - Elsevier
An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's …

MA Daulatzai - Journal of neuroscience research, 2017 - Wiley Online Library
Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

[HTML][HTML] Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models

MJD Daniels, J Rivers-Auty, T Schilling… - Nature …, 2016 - nature.com
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-
2 enzymes. The NLRP3 inflammasome is a multi-protein complex responsible for the …

[HTML][HTML] Alzheimer's disease and gut microbiota

X Hu, T Wang, F Jin - Science China Life Sciences, 2016 - Springer
Alzheimer's disease (AD) is a most common neurodegenerative disorder, which associates
with impaired cognition. Gut microbiota can modulate host brain function and behavior via …

[HTML][HTML] Therapies for prevention and treatment of Alzheimer's disease

J Mendiola-Precoma, LC Berumen, K Padilla… - BioMed research …, 2016 - hindawi.com
Alzheimer's disease (AD) is the most common cause of dementia associated with a
progressive neurodegenerative disorder, with a prevalence of 44 million people throughout …

[HTML][HTML] Alzheimer's disease and type 2 diabetes: a critical assessment of the shared pathological traits

S Chatterjee, A Mudher - Frontiers in neuroscience, 2018 - frontiersin.org
Alzheimer's disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most
prevalent diseases in the elderly population worldwide. A growing body of epidemiological …

Mitochondria and reactive oxygen species in aging and age-related diseases

C Giorgi, S Marchi, ICM Simoes, Z Ren… - International review of …, 2018 - Elsevier
Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Aging, lifestyle and dementia

D Wahl, SM Solon-Biet, VC Cogger, L Fontana… - Neurobiology of …, 2019 - Elsevier
Aging is the greatest risk factor for most diseases including cancer, cardiovascular disorders,
and neurodegenerative disease. There is emerging evidence that interventions that improve …