Symptomatic osteoarthritis (OA) causes substantial physical and psychosocial disability.
This article delineates the characteristic symptoms and signs associated with OA and how …

Angiogenesis and inflammation are closely integrated processes in osteoarthritis (OA) and
may affect disease progression and pain. Inflammation can stimulate angiogenesis, and …

Osteoarthritis can be defined as a disorder of movable joints characterized by deterioration
of articular cartilage, osteophyte formation and bone remodeling, changes in periarticular …

Objective The groin pain experienced by patients with hip osteoarthritis (OA) is often
accompanied by areas of referred pain and changes in skin sensitivity. We aimed to identify …

IFN-γ rapidly primes the macrophage via JAK1/2-STAT1 pathway so that it can subsequently
undergo a slower classical type 1 activation upon exposure to T helper (Th) 1 cytokines such …

The concept of an integrated bidirectionally regulated neuroendocrine-immune adaptive
response to stress has strong experimental support. The quality and inн tensity of this …

OBJECTIVE: The goal of the present study is to systematically review the scientific literature
addressing central sensitization and central nociceptive processing in patients with …

The nervous system in the intestine controls motility, secretion, sensory perception, and
immune function. Peptidergic neurones with neurotransmitters such as substance P and …

The immune and the nervous systems are anatomically closely related and interact with
each other by molecules common to both systems, such as cytokines and neurotransmitters …

From the compendium presented above, the following statements become evident: 1)
Inappropriately low secretion of cortisol in relation to inflammation is a typical feature of the …