The double burden of malnutrition: aetiological pathways and consequences for health

JC Wells, AL Sawaya, R Wibaek, M Mwangome… - The Lancet, 2020 - thelancet.com
Malnutrition has historically been researched and addressed within two distinct silos,
focusing either on undernutrition, food insecurity, and micronutrient deficiencies, or on …

Developmental origins of metabolic diseases

DJ Hoffman, TL Powell, ES Barrett… - Physiological …, 2021 - journals.physiology.org
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …

Origins of lifetime health around the time of conception: causes and consequences

TP Fleming, AJ Watkins, MA Velazquez, JC Mathers… - The Lancet, 2018 - thelancet.com
Parental environmental factors, including diet, body composition, metabolism, and stress,
affect the health and chronic disease risk of people throughout their lives, as captured in the …

[HTML][HTML] Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental …

C Cheroni, N Caporale, G Testa - Molecular autism, 2020 - Springer
The complex pathophysiology of autism spectrum disorder encompasses interactions
between genetic and environmental factors. On the one hand, hundreds of genes …

Principles of DNA methylation and their implications for biology and medicine

Y Dor, H Cedar - The Lancet, 2018 - thelancet.com
DNA methylation represents an annotation system for marking the genetic text, thus
providing instruction as to how and when to read the information and control transcription …

Intergenerational and transgenerational epigenetic inheritance in animals

MF Perez, B Lehner - Nature cell biology, 2019 - nature.com
Animals transmit not only DNA but also other molecules, such as RNA, proteins and
metabolites, to their progeny via gametes. It is currently unclear to what extent these …

[HTML][HTML] Immune dysfunction as a cause and consequence of malnutrition

CD Bourke, JA Berkley, AJ Prendergast - Trends in immunology, 2016 - cell.com
Malnutrition, which encompasses under-and overnutrition, is responsible for an enormous
morbidity and mortality burden globally. Malnutrition results from disordered nutrient …

African genetic diversity and adaptation inform a precision medicine agenda

L Pereira, L Mutesa, P Tindana, M Ramsay - Nature Reviews Genetics, 2021 - nature.com
The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …

[HTML][HTML] Adolescence and the next generation

GC Patton, CA Olsson, V Skirbekk, R Saffery… - Nature, 2018 - nature.com
Adolescent growth and social development shape the early development of offspring from
preconception through to the post-partum period through distinct processes in males and …

Obesity in low-and middle-income countries: burden, drivers, and emerging challenges

ND Ford, SA Patel, KMV Narayan - Annual review of public …, 2017 - annualreviews.org
We have reviewed the distinctive features of excess weight, its causes, and related
prevention and management efforts, as well as data gaps and recommendations for future …