Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Gap junctions are clustered channels between contacting cells through which direct
intercellular communication via diffusion of ions and metabolites can occur. Two …

The Ca2+ release channel ryanodine receptor 2 (RyR2) is required for excitation-contraction
coupling in the heart and is also present in the brain. Mutations in RyR2 have been linked to …

The cardiac electrical system is designed to ensure the appropriate rate and timing of
contraction in all regions of the heart, which are essential for effective cardiac function. Well …

Optical techniques have revolutionized the investigation of cardiac cellular physiology and
advanced our understanding of basic mechanisms of electrical activity, calcium …

Over the last decade, mouse models have become a popular instrument for studying cardiac
arrhythmias. This review assesses in which respects a mouse heart is a miniature human …

Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. Although
recent advances in cell-based models, including human-induced pluripotent stem cell …

Catecholaminergic polymorphic ventricular tachycardia (VT) is a lethal familial disease
characterized by bidirectional VT, polymorphic VT, and ventricular fibrillation …

Zebrafish and Xenopus have become popular model organisms for studying vertebrate
development of many organ systems, including the heart. However, it is not clear whether …

Gap junctions form the intercellular pathway for cell-to-cell transmission of the cardiac
impulse from its site of origin, the sinoatrial node, along the atria, the atrioventricular …