Clustered miRNAs and their role in biological functions and diseases
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
[HTML][HTML] Regulatory mechanisms of microRNA expression
LF Gulyaeva, NE Kushlinskiy - Journal of translational medicine, 2016 - Springer
MicroRNAs (miRs, miRNAs) are small molecules of 18–22 nucleotides that serve as
important regulators of gene expression at the post-transcriptional level. One of the …
important regulators of gene expression at the post-transcriptional level. One of the …
[HTML][HTML] Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers
Aurora kinase A (AURKA) is frequently overexpressed in several cancers. miRNA
sequencing and bioinformatics analysis indicated significant downregulation of miR-4715 …
sequencing and bioinformatics analysis indicated significant downregulation of miR-4715 …
MicroRNAs and epigenetics
C Moutinho, M Esteller - Advances in cancer research, 2017 - Elsevier
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression mainly at
the posttranscriptional level. Similar to protein-coding genes, their expression is also …
the posttranscriptional level. Similar to protein-coding genes, their expression is also …
[HTML][HTML] MicroRNAs: Tiny regulators of gene expression with pivotal roles in normal B-Cell development and B-Cell chronic lymphocytic leukemia
Simple Summary The involvement of miRNAs in physiological cellular processes has been
well documented. The development of B cells, which is dictated by a miRNA-transcription …
well documented. The development of B cells, which is dictated by a miRNA-transcription …
Epigenetic deregulation in chronic lymphocytic leukemia: Clinical and biological impact
L Mansouri, JA Wierzbinska, C Plass… - Seminars in cancer …, 2018 - Elsevier
Deregulated transcriptional control caused by aberrant DNA methylation and/or histone
modifications is a hallmark of cancer cells. In chronic lymphocytic leukemia (CLL), the most …
modifications is a hallmark of cancer cells. In chronic lymphocytic leukemia (CLL), the most …
MicroRNA miR-34a downregulates FOXP1 during DNA damage response to limit BCR signalling in chronic lymphocytic leukaemia B cells
The variable clinical course in chronic lymphocytic leukaemia (CLL) largely depends on p53
functionality and B-cell receptor (BCR) signalling propensity; however, it is unclear if there is …
functionality and B-cell receptor (BCR) signalling propensity; however, it is unclear if there is …
MiR‐34b/c‐5p and the neurokinin‐1 receptor regulate breast cancer cell proliferation and apoptosis
L Zhang, L Wang, D Dong, Z Wang, W Ji, M Yu… - Cell …, 2019 - Wiley Online Library
Objectives MiR‐34 is a tumour suppressor in breast cancer. Neurokinin‐1 receptor (NK1R),
which is the predicted target of the miR‐34 family, is overexpressed in many cancers. This …
which is the predicted target of the miR‐34 family, is overexpressed in many cancers. This …
Epigenetic regulation of human non-coding RNA gene transcription
M Morselli, G Dieci - Biochemical Society Transactions, 2022 - portlandpress.com
Recent investigations on the non-protein-coding transcriptome of human cells have
revealed previously hidden layers of gene regulation relying on regulatory non-protein …
revealed previously hidden layers of gene regulation relying on regulatory non-protein …
Methylation of the HOXA10 promoter directs miR-196b-5p–dependent cell proliferation and invasion of gastric cancer cells
The cross-talk between epigenetics and miRNA expression plays an important role in
human tumorigenesis. Herein, the regulation and role of miR-196b-5p in gastric cancer was …
human tumorigenesis. Herein, the regulation and role of miR-196b-5p in gastric cancer was …